A medical gentleman of high standing, in an adjoining county, who has recently abandoned the common use of tobacco, informed me, that on a certain occasion his muscular and vital energies were so overcome, by chewing, that in attempting to put his horse into the stable, he was obliged to lie down until he had so far recovered his strength as to enable him to proceed to his house. Many other instances were related by the same gentleman, of its injurious effects which he had observed, both on himself and others; particularly in producing watchfulness, which it was almost impossible for the greatest degree of weariness and fatigue to overcome. Many others have frequently mentioned this fact to me, since I began to investigate this subject. Now if tobacco produces no effect, why are such results witnessed by its consumers, and why do the candid among them acknowledge that these evils arise from its use? The health of the medical gentleman above named was materially improved after laying aside tobacco; and those to whom he recommended a similar course, have experienced a like favorable result. The second position is equally unsupported either by experience or sound reasoning; and is contrary not only to all medical authority on this subject, but against the investigations of other scientific men who have chemically examined the constituent principles of tobacco, and who have experimented largely to ascertain with precision its natural operation on the living fibre. The lower order of animals have been selected for these experiments. Given in substance to them, it has uniformly proved fatal, even in very minute doses. When its expressed juice or essential oil has been introduced under the skin of pigeons, kittens, or rabbits, it produced violent convulsions and often instantaneous death. Does any one doubt the correctness of these experiments? He can easily satisfy himself of their accuracy, by obtaining the oil of tobacco, and applying eight or ten drops to the root of a kitten's tongue. The same deadly effects, as we have seen, uniformly attend its first application to the human system, if taken to any considerable extent. This is well understood by its consumers, who are very cautious for many weeks, and even months, how they deal with the poisonous drug.