It was undoubtedly these discussions that turned Mary Lyon's mind and thoughts to spiritual things. Heretofore, she had been so absorbed in her passion for general knowledge that the matter of religion had never touched her. Suddenly the fact burst upon her that all things in this life were useless and unsatisfying, except as they were used in helping humanity. From this time on, her work of teaching seemed little short of inspired. When, later, an assistant was wanted at Sanderson Academy, notwithstanding the opposition of many who believed that a man should fill the place, Mary Lyon was selected for the position. Before long one of her former teachers, Miss F. P. Grant, sent for her to fill a higher position at Derry, New Hampshire. Mary delayed going in order to take some lessons in chemistry from Professor Eaton of Amherst. The school in Derry numbered ninety pupils. It was held only during the summer months, and during the winter Mary again taught at Ashfield and Bucklands. She charged twenty-five cents a week for tuition, the scholars boarding with families in the vicinity, at the rate of $1.25 weekly. Meanwhile Miss Grant, who had removed to Ipswich, induced Miss Lyon to join her there. Together they conducted the Ipswich Academy, and together they worked out their ideas of what a school should be. During these years of teaching, Mary Lyon's heart had been full of sympathy for girls who desired an education but could not obtain it. There were no scholarships offered in those days and the doors of men's colleges were closed to women. At Ipswich, Mary found it impossible to conduct a good school on the income derived from the fees of the pupils. So she tried to interest wealthy men, ministers, and college presidents in her plan of forming a high-grade school or college for women, asking those who were able, to donate a sum of money for the purpose. Most of these men refused to aid her in the project, repeating the old story that "girls had no need for a knowledge of science or the classics; that, in fact, they were unfitted for studying advanced branches." Miss Lyon held a quite different view, and stuck to her purpose through every discouragement. Yet, sometimes even brave Mary Lyon had moments of despondency, when she would weep bitterly over her failure to interest others in her plans. But the idea of giving up the work never crossed her mind. She often said to her pupils, "If you feel depressed, think of others, not of yourself!" About this time she refused a good offer of marriage, saying that her life was devoted to one purpose and that she must give herself entirely to her work. She prayed, and begged her mother to pray, for success. Over and over again she would say: "Commit thy way unto the Lord. He will keep thee. Women _must_ be educated. They _must_ be!"