The pacification and consolidation of Castile was followed by the conquest of Granada. The Holy Brotherhood served the purpose of a standing army, internal feuds among the Moors aided the Christians, and after a protracted struggle (1481-1492) the city of Granada was taken, and the Moorish rule in the Peninsula ceased. All Spain, save Portugal and Navarre (seized by Ferdinand in 1512), was thus united under Ferdinand and Isabella, the Catholic Sovereigns as they came to be called, and the civil unity increased the desire for religious uniformity. The Jews in Spain were numerous, wealthy, and influential. They had intermarried with many noble families, and almost controlled the finance of the country. It was resolved to compel them to become Christians, by force if necessary. In 1478 a Bull was obtained from Pope Sixtus IV. establishing the Inquisition in Spain, it being provided that the inquisitors were to be appointed by the sovereign. The Holy Office in this way became an instrument for establishing a civil despotism, as well as a means for repressing heresy. It did its work with a ruthless severity hitherto unexampled. Sixtus himself and some of his successors, moved by repeated complaints, endeavoured to restrain its savage energy; but the Inquisition was too useful an instrument in the hands of a despotic sovereign, and the Popes were forced to allow its proceedings, and to refuse all appeals to Rome against its sentences. It was put in use against the Moorish subjects of the Catholic kings, notwithstanding the terms of the capitulation of Granada, which provided for the exercise of civil and religious liberty. The result was that, in spite of fierce rebellions, all the Moors, save small groups of families under the special protection of the Crown, had become nominal Christians by 1502, although almost a century had to pass before the Inquisition had rooted out the last traces of the Moslem faith in the Spanish Peninsula. The death of Isabella in 1504 roughly dates a formidable rising against this process of repression and consolidation. The severities of the Inquisition, the insistence of Ferdinand to govern personally the lands of his deceased wife, and many local causes led to widespread conspiracies and revolts against his rule. The years between 1504 and 1522 were a period of revolutions and of lawlessness which was ended when Charles V., the grandson of Ferdinand and Isabella, overcame all resistance and inaugurated a reign of personal despotism which long distinguished the kingdom of Spain. Spanish troubles had something to do with preventing Charles from putting into execution in Germany, as he wished to do, the ban issued at Worms against Martin Luther. § 6. Germany and Italy.