For it is not only (if at all _Primarily_) from an Obstruction of the _Biliary Canals_ that this Symptom does proceed, but also from any Cause whatsoever, which either destroys the Saline Part of the Bile, by the means of which its Oil is kept mixt with the Water of the Blood, or else increases the Oily and Sulphureous Part to that Degree, that tho’ it be duly impregnated with Salt, yet the Watery Part of the Blood, which can only take up a certain Proportion of it, being already _Saturated_, can receive no more; or lastly, does, by _disuniting_ the compounding Particles of the Blood, alter that _Intestine_ Motion and Agitation which is necessary to carry along thro’ the Vessels, together with the more volatile Parts, those which are more Clammy and Glutinous. For in all these Cases ’tis plain that the Bilious Corpuscles must be _præcipitated_ upon those Parts of the Body where there is least Motion, that is, upon the extreme Superficies. And tho’ this Theory may perhaps appear extravagant, because new and uncommon, yet it will not, I believe, seem ill grounded or irrational to those who understand the Doctrine of the _Mixture_ of Heterogene Fluids, and their _Separation_; and who withal know, that the Vessels are rarely obstructed, unless it be from the fault of the Liquid they carry, and consequently that a Defect in the Bile it self must be (excepting some extraordinary Cases) antecedent to the Obstruction of the Biliary Ducts. In short, the different Cure of this Disease confirms these Notions; for an _Icterus_ from the first Cause assign’d, which is generally owing to a sedentary Life, want of Exercise, _&c._ and attended with an extreme Costiveness and white _Fæces_, is cured by Volatile, Acrimonious, and Bitter Salts. From the Second produced oftentimes by drinking strong Liquors, Spirits, _&c._ and accompanied with a _Diarrhœa_, partly by Diluting and Temperating, partly by Stomachic and Strenghning Medicines. As the last Species of it (for the sake of which we have mention’d the other) is removed by such _Antidotes_ as overcome and destroy the Venomous Ferment, corrupting the Blood, and breaking its _Compages_. But to have hinted these things may abundantly suffice for the present. We must however take Notice, That _tho’_ the _main_ Alterations made by this Poison be in the Fluid of the Arteries, _yet_ that _That_ of the Nerves may hereby be considerably _changed_ too; for _This_ consisting, as well as the Blood of differing Parts, and being dispersed in small _Tubes_ all over the Body, is not only very capable of _various_ Degrees of _Force_, _Impulse_, _&c._ but _Undulating_ continually towards the Brain, and being the chief Instrument of Motion and Action, may perhaps sometimes more immediately convey the Mischief to the sensile Membranes, and thus be the Cause of those violent Pains, Convulsions, Sickness, _&c_ with which Those who are Bitten are presently seiz’d.