The want of this may be one Reason why the Experiment of first making a Wound in the Flesh with any sharp Instrument, and then dropping in the _Sanies_, may not always succeed so well in killing Animals, as one would from the preceeding Doctrine be ready to expect. Tho’ if some amends be made for this Defect, by taking a greater quantity of the Juice, and carefully instilling it, It proves equally Fatal this way, as when immediately discharg’d from the Viper it self. Thus it might happen that those Trials of this kind, which were happily made by S^r _Redi_, might not however convince M^r _Charas_, in as much as there is oftentimes a great deal of difference in the Event of Experiments, when made with Purpose, and a Design that they should succeed, and when Timorously and Cautiously managed, lest they should unluckily overthrow a darling _Hypothesis_. The other Observation I shall draw from the foregoing Theory, is this, That it appears from hence what a vast _variety_ there may be in the Fermentations even of one and the same Fluid; for these being no other than _Changes_ made in the _Cohæsion_ of the compounding Particles, are capable of as many Alterations as _Motion_ in its _Degrees_ and _Directions_ can admit of, which are really Infinite. This I mention with regard to some of the following _Essays_, in which, if we ascribe many Symptoms seemingly very different, to a Ferment rais’d in the Blood, it may be consider’d, that the Nature of this Cause is such, as according to the several Properties of the _Primum Agens_, or _Fermenting Power_, to bear by far more Varieties than any one can be aware of. To return to the Viper; the Effects of such an Agitation of the Blood, as we have been describing, must not only be whatever are the Consequences of a disturbed _Circulation_, and irregular and interrupted _Secretion_ of the Spirits, as low Pulse, Faintings, Sickness, Palpitation of the Heart, Convulsive Vomitings, Tremblings of the Body, _&c._ but also the _Texture_ of this Fluid being thus broken, those Parts of it which are of the slowest Motion, and greatest Viscidity, will be easily separated from the others; such they are, which when united together do compound the _Bile_, and therefore these will tinge the Capillary Vessels, and fine _Ducts_ in the Skin, with a Yellowish Colour; that is, will induce an _Icterus_, or Jaundice.