Two other matters remain to be noticed. The first of these is Naegeli's use of the German word _Anlage_. We have been unable to give a perfectly satisfactory translation of this word in its technical meaning. We have received some comfort, though but little help, from the experience of the translators of similar works. Selmar Schoenland, in translating from Weismann, renders it variously as "germ," "germ of structure," "germ (of Naegeli)," "germ of Naegeli," "Naegeli's preformed germ of structure," "preformed germs," "tendency." Another translator renders the word as "constitutional element." The translation, "determinant," which we have selected is an appropriation of an analogous but not absolutely identical technical term from Weismann's _Germinal Selection_. The use of the word in this connection is open to the objection that it has previously been used technically for a somewhat different idea by another author. M. C. Potter, in his translation of Warming's _Systematic Botany_, following Dr. E. L. Mark, renders the word _Anlage_ as "fundament." Dr. H. C. Porter, in his translation of the _Bonn Text-Book of Botany_, renders the same word as "rudiment." In general the word Anlage means beginning, plan, disposition to anything, and hence involves the ideas of origin, organization and tendency. Sanders defines the word in one of its meanings as: "The act of planning or beginning anything; the act of laying the foundation of any work intended to be carried on toward completion, in order that from the beginning made, a definite thing may be developed or may develop itself"; (_i.e._, to determine, in the sense of limiting to a particular purpose or direction, hence determinant). "Also, the thing begun or planned, considered as the basis and germ of the further development of that which has already originated." In its restricted use as applied to organisms it would mean "germ," in the sense of embryonic starting point. More specifically, it is a portion of plastic, organized substance, functioning as an individual and containing potentially an elemental organ plus a formative power. In Naegeli's own words, "There exists an essential difference between the substance of a mature organism which does not possess the capability of further development, and the substance of an egg, which does possess this capability. By virtue of this difference the egg-substance is characterized as the _Anlage_, or germ of the mature organism. All characteristics of the adult condition are potentially contained in the ovum." Naegeli was not the first to assume the existence of a unit of organization intermediate between the molecule and the cell. E. B. Wilson, in his _The Cell in Inheritance and Development_, states the case as follows: