Cancer of the liver, in the majority of instances, is secondary to cancer of some other part, as of the stomach, rectum, or female breast. In more than one-third of the cases, it is said to be secondary to cancer of the stomach. Cases are rare where the liver is primarily affected with cancer. Before thirty-five or forty years of age, secondary cancer seldom occurs. The following cases will serve to illustrate the two forms of cancer of the liver: CASE I.—_Primary Cancer of the Liver, with great enlargement—Rupture of Stomach from post-mortem softening._ Mrs. K——, aged 38, light complexion, short and fleshy, commenced complaining about New Year’s, 1868, of pain in the “stomach,” as she expressed it, with loss of appetite, restlessness at night, accompanied with weakness and prostration. These symptoms continued for a couple of weeks, when she commenced to complain of soreness in stooping, and inability to wear her clothes tight. This led to an inspection of the abdomen in bed. I then found projecting below the margin of the chest on the right side, a hard rounded tumor, nearly of the size of the fist, somewhat sensitive to the touch, and evidently springing from the liver. The pain daily increased in severity, and coming on as it did, in paroxysms, resembled much the pain attending the passage of biliary calculi. After she took to her bed, which was in the latter part of January, there was a rapid increase in the size of the liver, with a marked aggravation of all the symptoms. The pain was most agonizing; slight chills occurred from day to day; the flesh rapidly wasted, and the outline of the lower border of the liver could be distinctly traced through the abdominal walls. There were no symptoms of jaundice. The skin was pale and waxen in hue. In the latter part of February, frequent epistaxis, and bleeding of the gums set in, while from the pressure upwards upon the diaphragm, the lungs were so embarrassed as to give rise to great dyspnœa. Rapidly sinking, she died on the first of March. _Autopsy_, made thirteen hours after death. Anterior portion of the body pale; posterior dark from gravitation of the blood. Rigor mortis scarcely noticeable. Upon opening the abdomen, found four to six ounces of serum in the peritoneal cavity. The liver was enormously enlarged, filling a great portion of the abdominal cavity, pushing the diaphragm high up into the chest, and giving the lungs less than half their normal amount of room for expansion. The upper surface of the right lobe was found adhered to the under surface of the diaphragm, and to the anterior abdominal walls, and the under surface to the stomach, duodenum and transverse colon. The surface of the liver was dark, mottled, and somewhat nodulated. The whole gland was quite firm, yet evidently just entering upon a softened stage at numerous points. No trace of an abscess forming at any point.