CASE I.--Mr. J. F., aged forty-four years. Removed to Reception Hospital on suspicion of typhus fever, December 8, 1893, when the following history was obtained: Patient was taken ill on December 3. On the following day, December 4, great weakness was experienced. Gradually became worse. Epistaxis, etc. On December 7 an eruption appeared. On December 8 the patient presented the following appearance: Face uniformly red, or of a dusky hue, and swollen; on close examination a faintly papular condition was apparent. Over chest, abdomen, and extremities was found a profuse papular eruption, of a very dusky or violet-colored hue. On the abdomen some of the papules had coalesced. Papules were noticeable on the hands and feet, particularly on the palms. On the inner surface of the thighs the entire skin presented the appearance of a scarlatinous eruption, although darker in color. Pressure on the surface did not leave a white streak or spot typical of scarlet fever. In some parts of the body papules were found which were almost black. At this time, December 8, there was no evidence of vesication. On December 9, the third day of the eruption, the latter presented no particular change in its appearance or progress. It still remained papular. Intense depression and delirium were present. At 3 P.M., December 9, the patient was removed to North Brothers Island. On December 10, the fourth day of the eruption, a few vesicles appeared for the first time. These formed slowly about the lower part of the abdomen and thighs. At these sites were four or five typical umbilications. On December 11, the fifth day of the eruption, many more umbilications were found. The patient became rapidly worse, and died on the following day, December 12. CASE II.--Mr. F. S., aged twenty-four years. Removed to Reception Hospital on suspicion of typhus fever. On December 8 the appearance of this case was similar to Case I., inasmuch as the face was swollen and presented an erysipelatous appearance, although the color was more of a dusky hue. Large erythematous patches, suggestive of scarlet fever, were found covering different parts of the body. The same condition was present in this case as was noticed in Case I.,--_i.e._, the color of the patches was darker than in scarlet fever, and when the finger was drawn over the patch it did not leave a white line. No patches were found on the arms; but at these sites were dark, almost black, papules, which slowly became vesicular and umbilicated. The eruption was confluent on the upper part of the thighs and the face, and the patient died on December 8.