My own experience with this method is limited to the observation of a few cases treated at the Riverside Hospital in 1893. Under the direction of Dr. Cyrus Edson, health commissioner, one ward was fitted with red glass windows. The cases treated were of a mild type, and although no deaths occurred, the disease appeared to run its usual course and the experiment was negative as to results. In reply to a letter of inquiry, Dr. Edson writes me that “if the results had not been negative a very careful report would have been made.” For the advancement of therapeutic knowledge it is indeed unfortunate that while the enthusiast is always so ready to write, the sceptic or unsuccessful experimenter is usually inclined to remain silent. *Period of Suppuration.*--With the transformation of the smallpox vesicles into pustules a rise of temperature occurs which is commonly known as the “secondary fever,” and in severe cases the swelling of the face, hands, and feet usually occasions the most intense suffering. The chief dangers of this stage arise from the possibility of septic poisoning and the probability of a greater or less degree of exhaustion. A nutritious diet is now of the utmost importance, and in severe cases bouillon, malted milk, or other prepared foods which can be readily swallowed should be given every two or three hours. If the patient is in a stupor, he may be awakened in order to receive the necessary nourishment, but the calm, refreshing sleep which sometimes follows a period of wakefulness and complete exhaustion should not be disturbed. Alcoholic stimulants are usually of great service in this stage and may be given freely, especially at night and in the early morning hours when the patient’s vitality is at its lowest ebb. In case of delirium, rectal alimentation will often be found necessary as a substitute for or a supplement to oral feeding. The rectum should first be thoroughly cleansed by an enema of soap and water and then from four to six ounces of milk and brandy or eggnog may be injected.