A large number of cases of epilepsy form the basis of the statistics, the great majority of whom are adults. No selection of any kind is made, and all are admitted irrespective of the cause, nature, or severity of the disease. The particulars of each having been noted, treatment by the bromides was instituted, the minimum dose being one drachm and a half daily,[G] which, if necessary, was further increased in quantity. The progress of the patient was observed at frequent and regular intervals, and if the attendance was irregular the case was excluded from the present inquiry. The result of this proceeding is an aggregate of 141 cases, all of whom have been constantly under the influence of the drug for periods varying from one to six years. These are arranged in groups according to the length of time they were under treatment. The immense mass of details thus collected, added to the varied circumstances connected with individual cases, render it impossible, in constructing a summary of the whole, to do more than select certain prominent features of interest for examination and demonstration. These in tabular form are as follows:-- TABLES SHOWING THE EFFECTS OF THE CONTINUOUS ADMINISTRATION OF THE BROMIDES IN THE EPILEPTIC STATE, IN 141 CASES, THE CONDITION BEING ASCERTAINED AT THE END OF EACH PERIOD. I. _For one year (51 cases)._ Physical and mental powers unaffected 39, or 76.4 per cent. Physical and mental powers impaired 6, or 11.7 per cent. Physical powers alone impaired 3, or 5.9 per cent. Mental powers alone impaired 2, or 3.9 per cent. General symptoms of neurasthenia 13, or 25.4 per cent. Bromide eruption 8, or 15.6 per cent. II. _For two years (34 cases)._ Physical and mental powers unaffected 28, or 82.3 per cent. Physical and mental powers impaired 2, or 5.8 per cent. Physical powers alone impaired 1, or 2.9 per cent. Mental powers alone impaired 2, or 5.8 per cent. General symptoms of neurasthenia 5, or 14.7 per cent. Bromide eruption 6, or 17.6 per cent. III. _For three years (30 cases)._ Physical and mental powers unaffected 28, or 93.3 per cent. Physical and mental powers impaired 1, or 3.3 per cent. Physical powers alone impaired 1, or 3.3 per cent. Mental powers alone impaired 0, or 0.0 per cent. General symptoms of neurasthenia 3, or 10.0 per cent. Bromide eruption 3, or 10.0 per cent. IV. _For four years (16 cases)._ Physical and mental powers unaffected 12, or 75.0 per cent. Physical and mental powers impaired 0, or 0.0 per cent. Physical powers alone impaired 2, or 12.5 per cent. Mental powers alone impaired 2, or 12.5 per cent. General symptoms of neurasthenia 0, or 0.0 per cent. Bromide eruption 2, or 12.5 per cent.