5. Secondary Small Pox is, for the most part, very mild in its symptoms, and of shorter duration than a first attack, insomuch as to have frequently given rise to doubts respecting the real nature of the disease. 6. Secondary attacks of Small Pox have, nevertheless, occasionally proved fatal. 7. When artificially produced by inoculation, the Small Pox is rendered materially milder in its character, so that one in two hundred only of those to whom the disease has been thus communicated, have been found to die in consequence. 8. The Small Pox, when communicated by inoculation, is probably as secure a preventive of any future attack of the disease as when it has taken place naturally. 9. Notwithstanding the undeniable advantages which accrued to those who passed through the process, it was, nevertheless, the direct effect of inoculation, by multiplying the sources of infection, materially to encrease the aggregate mortality occasioned by Small Pox. ------------------------------------------------------------------------ CHAP. III. Such having been proved to have been the destructive consequences of Small Pox, previous to the introduction of Vaccination, we are fully prepared to enter upon the second query proposed,—What influence has Vaccination exerted over these consequences—1. by extensively superseding the cause—and 2. by essentially interfering with the effect? The name of Dr. Jenner is too intimately associated with the subject of Vaccination to admit of the latter being referred to without some allusion being made to the former; and I should ill testify my sense of the truly valuable blessing which Jenner has been the means of conferring upon mankind, were I altogether to omit any expression of my admiration of the superior perception which enabled him to infer the probable consequences of facts, which must have been long familiar to hundreds without having given rise to any important suggestion, and of the zeal and ability with which he prosecuted his enquiries on the subject, or my high esteem for the generous disinterestedness with which he made known to the world his most useful discovery. “It will,” (to use the words of Sir Gilbert Blane,) “in the eyes of future ages, be deemed an epocha in the destinies of the world, and one of the highest boasts of the country in which it took its rise, with a sense of unrequitable obligation to the individual who first disclosed and promulgated the secret, by drawing it from the dark recesses of rural tradition, and rendering it available to the whole human race.”