Sir Gilbert goes on to say, that “it is now matter of irrefragable historical evidence, that Vaccination possesses powers adequate to the great end proposed by its meritorious discoverer, in his first promulgation of it in 1798, namely, the total extirpation of Small Pox. The first proof of this was at Vienna, where, in 1804, no cases occurred, except two strangers, who came into the city with the disease upon them. In 1805 there did not occur a single death from it in Copenhagen. Dr. Sacco, the indefatigable superintendent of Vaccination in Lombardy, stated in his annual report, 3d January, 1808, that the Small Pox had entirely disappeared in all the large towns in that country; and that in the great city of Milan it had not appeared for several years. Dr. Odier of Geneva, so favourably known for his high professional, scientific, and literary acquirements, testifies that, after a vigorous perseverance in Vaccination for six years, the Small Pox had disappeared in that city and the whole surrounding district; and that, when casually introduced by strangers, it did not spread, the inhabitants not being _susceptible_. The central committee in Paris testify, in their report of 1809, that the Small Pox had been extinguished at Lyons and other districts of France.” “These are selected as some of the earliest and most remarkable proofs of the extirpating power. But it is demonstrable, that if at the first moment of this singular discovery, at any moment since, at the present or any future moment, mankind were sufficiently wise and decided to vaccinate the whole of the human species, who have not yet gone through the Small Pox, from that moment would this most loathsome and afflicting of all the scourges of humanity, be instantaneously and for ever banished from the earth.” (p. 8). These, and such as these, then are the great, the undeniable facts, which must, I think, carry irresistible conviction to every reflecting and unprejudiced mind respecting the true value of Vaccination. And it is these facts which furnish us with an answer to the second question proposed—What influence has Vaccination exerted over the destructive consequences of Small Pox? which it must be truly gratifying to every philanthropic mind to contemplate. In the course of twenty-five years, in our own country, where it has been very partially employed, it has actually been the means of saving a number of lives, amounting to 393,356; and if it be true, as supposed by Sir Gilbert Blane, that Small Pox induced “blindness, deformity, scrofula, or broken constitutions,” in as many who recovered from the disease as died in consequence of it, then have an equal number been saved from these dreadful calamities. But abroad, where it has been more generally employed, Vaccination has, in many places, actually exterminated the Small Pox altogether.