If the reactive force of the organism was still sufficient, the medicine succeeded very speedily in preventing the supervention of the typhoid stage, in changing the fever-type from a remittent or even continuous to an intermittent type, during which the convalescence of the patient, aided by a suitable diet, was more and more firmly established and generally completely secured after the lapse of a week. If the typhoid stage could not be prevented and set in with the following symptoms: the patient lies on his bed in a state of apathy, with loss of recollection, sopor, muttering delirium, hardness of hearing, inability to protrude the tongue or to articulate; dry, cracked, sore, blistered, ulcerated tongue; difficult deglutition; painful distention of the abdomen, which is sensitive to contact or pressure; retention of stool, or else frequent, painful, foul, bloody, involuntary diarrhœa; fermentous urine, which is sometimes discharged involuntarily; the skin is at times and partially dry, burning, at times and partially clammy, cool; trembling and twitching of the limbs; white miliaria on the chest and abdomen; extreme debility, with settling towards the foot-end of the bed; changing pulse, which is at times slow, at others accelerated, feeble, intermittent: in such a case Apis requires more time to heal the mucous membrane of the alimentary canal; to restore the normal action of the bowels; to regulate the digestive functions; to procure quiet and refreshing sleep, and to gradually effect a complete restoration of health. If the mucous membrane of the respiratory organs was invaded by the morbid process, the cure was nevertheless completed as soon as the mucous lining of the intestinal canal was restored to its natural condition.