So far, the only obstacle to a cure which I have witnessed, has been tuberculosis of the chest or abdominal viscera, or of both at the same time, and still more the vaccine-virus; likewise a tendency to paralysis in persons who were otherwise morbidly affected. Tuberculosis has often been combated by a single dose of a high potence of Sulphur between the doses of Apis, no Apis being given after the Sulphur, as long as the course of the typhoid symptoms would render it safe to postpone this medicine. I have found it much more difficult to conquer the vaccine-poison, _which I have become satisfied by years of observation, constitutes the most universal and most powerful generator of the typhus which is prevailing in our age and which seems unwilling to leave us_. Tartar emetic proves in this, as in other cases, its antidotal power against the vaccine-virus; but under no circumstances is more caution required in the use of tartar emetic than in typhus, where the vaccine-virus seeks to develop its characteristic pustules with a tendency inherent in each pustule to terminate in the destruction of the mucous membrane. It may seem hazardous to add to this combination of destructive forces another similarly-acting element; but a careful consideration of the circumstances of the case will justify such a proceeding, although death may be the inevitable result of the morbid process. Experience has satisfied me that the alternate use of tartar emetic and Apis, a drop of the third potency of each, every three, six or twelve hours, according as the symptoms are more or less violent, or, in very sensitive organisms, in tablespoonful doses of a watery solution of a drop, will accomplish all that can be expected; for these two drugs, thus administered, seem to compensate or complete each other. I am unable to say how far this proceeding requires to be modified in particular cases; all I desire to do, is to submit this important subject to my colleagues for further inquiry and trial. If a tendency to paralysis prevails, the danger is less threatening, although equally momentous. In such cases I use Apis and Moschus in alternation, although I am unable to assert, on account of deficient experience, that this treatment will always prove satisfactory. Such cases hardly ever arise under homœopathic treatment; and if they come to us out of the hands of allœopathic practitioners, they generally prove incurable. If these three obstacles to a cure appear combined, I have never found it possible to effect any thing. All that I have found it possible to do, has been to prevent such a dreadful combination by carefully attending to my patients in previous diseases.