Hence Dr. Davies, under whose direction these cases occurred, remarks, in view of this result, "that _no reliance_ could be placed on chloroform alone." The correctness of this opinion cannot be questioned, for the experiments we have cited all show the necessity of a prompt and diffusive stimulant in aid of its action, to render it sufficiently prompt and powerful to meet and overcome the disease in the more rapid and severe cases. Chloroform, properly combined, offers the best hope of relief, and is, without doubt, the most perfectly adapted of any remedy known to the pathology and phenomena of the disease. There is no remedy, when properly combined, so capable of meeting all the indications required as this, and none that can be administered with more certainty of success. In conclusion, we may, with much propriety, refer again to the pathology suggested by the authors cited above, and inquire whether the action of chloroform as a remedy in these cases be consistent? and whether as such it has that curative influence, or direct controlling power, to arrest, suspend, and cure the disease, so imperiously demanded? We have seen that, according to the opinion generally prevailing, the first impression of the poison is made upon the blood, and through it upon the nerves, especially those which, from their anatomical position, bear the most intimate relation to the blood-vessels. Through this channel the first invasion appears to be made on the ganglionic, the nerves of circulation. These nerves are distributed chiefly to the viscera and blood-vessels, and are at least very early involved and essentially disturbed, for their healthful action depends in no small degree on the aeration or oxydation of the blood. Says an eminent author, "The action of every ganglionic mechanism depends on the existence of certain physical conditions, among which the most prominent and important is the due supply of arterialized blood. If this be stopped but for a moment the nerve mechanism loses its power, or, if diminished, the display of its characteristic phenomena correspondingly declines." Hence the loss of power in these nerves, and their deranged action, the contraction of the capillary and pulmonary arteries, the impaired and impeded circulation and all the phenomena arising therefrom. Again, the great pneumogastric nerve, which is composed of both motor and sensitive filaments, has a very extensive distribution in the upper part of the abdominal cavity. It supplies the organs of voice and respiration with motor and sensitive fibres, and the pharynx, oesophagus, stomach and heart with motor influence. This very important nerve, through the primary action and deteriorating process of the cholera poison, becomes early involved, and its functions greatly, and, in fatal cases, permanently deranged. The evidence of this disturbance and loss of nerve-power is too obvious to be overlooked or disregarded in the treatment of this disease.