_Experiment No. 6._--February 19, 1906, a large gray rabbit weighing 2,055.3 grams was fed with 60 c.c. of fluid representing the concentrated aqueous extract of 250 grams of the fresh _Astragalus mollissimus_, collected September 18, 1905, and preserved in chloroform. This rabbit was very hard to hold. The ears rested on the body. The temperature at the time of feeding, 1.30 p.m., was 102.3°F. At 2.57 p. m. the animal looked dull but resisted handling. At 3.30 p.m. it urinated. At 4.15 p.m. the temperature was 98.5°F., the pupils were about the same size as before feeding, and the animal became much duller. The next day at 12.50 p.m. the temperature was 102.4°F., and at this time the animal could be handled with greater ease. The animal ate in the morning. The same amount of extract was again fed at 1.24 p. m. At 1.35 p.m. the animal was much duller and could be turned on his back with ease. If disturbed he ran against the wall as if utterly unconscious of the obstruction. The animal had soft, liquid, brown stools and tried to lie down as much as possible. If turned on its back with the feet up it would stay so almost indefinitely. Temperature, 103.8°F.; respiration very rapid. At 2.40 p.m. the temperature was 99.8°F., and the animal died a few minutes later. After death the pupils were much contracted. The vessels of the dura covering the brain were much dilated, but the vessels inside the brain were not dilated. The stomach walls were congested and marked with numerous petechiæ and covered with mucus.