=Typhoid, Measles, Tuberculosis.=--Transfusion has been tried for
several other bacterial infections with varying results. McClure has
administered immunized blood to a typhoid patient with a remarkably
good result. Ottenberg and Libmann have transfused five typhoid
patients, all of whom were desperately ill; two of them recovered.
Transfusion has also been used for intestinal hæmorrhage in typhoid,
but this is chiefly with the object of combating anæmia. Subcutaneous
injection of blood has been successfully used by Terrien in a case of
malignant measles; the donor had had measles six months previously.
Freilich has recently transfused six patients suffering from
tuberculosis, but without benefit. He is at present testing the use
of blood from donors who show a positive complement fixation test for
the tubercle bacillus.
It is evident that treatment with immunized blood is still in
an experimental stage, but it merits further trials, all the
circumstances of which should be carefully recorded.
=Toxæmias of Pregnancy.=--The treatment of eclampsia by blood
transfusion was first employed by Kimpton, who speaks favourably of
the results obtained. Later it was independently suggested to Blair
Bell, who was the first to employ it in this country, by certain
investigations into the facts of immunology. It had been found that
symptoms resembling those of eclampsia could be produced in mice by
injecting into them an extract of placenta, whether from a healthy or
an eclamptic woman; the same results were obtained by injecting fresh
serum from similar individuals. Further, if the placental extract was
mixed with serum from a normal person of either sex, the effects were
not obtained, and it was inferred that the placental toxin had been
neutralized by antibodies in the serum. If, however, the placental
extract was mixed with serum obtained from the blood of an eclamptic
patient, then the toxic symptoms were obtained as before. Apparently,
therefore, the serum in eclampsia lacks certain antibodies which are
present in the serum of normal individuals. If these observations
had been correctly interpreted, it seemed reasonable to suppose
that blood from a normal person would supply an eclamptic patient
with the antibodies which she lacks. The patient treated by Blair
Bell was already comatose and apparently dying. She was given 500
cc. of citrated blood and rapidly recovered; her convalescence was
uninterrupted. It would be unwise to found great hopes on a single
case, but the treatment undoubtedly merits further trial.
Transfusion has also been used by Keator in treating the toxæmia
of early pregnancy, and Morel has successfully used the blood of a
healthy pregnant woman for the same purpose. Gettler recommends the
use of alkalinized blood for “acidosis” in pregnancy. At present,
however, little evidence can be adduced in favour of this form of
treatment.
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