4.10--5 minutes .16--4.5 “ .25 to .28 Stimulation of left splanchnic (glandless). .30--4.5 minutes .35--4.5 “ .40--7.5 “ .49 to .51 Stimulation of right splanchnic. .55--4.5 minutes 5.00--2.5 “ .14--6 “ .23 to .25 Stimulation of right splanchnic. .26--6 minutes .33--4.5 “ .38--3.5 “ .43--4.5 “ .49--5 “ .55--6 “ The results in this experiment are represented graphically in Fig. 31. [Illustration: Figure 31.--Results of stimulating the left splanchnic nerves, 4:25-:28, after removal of the left adrenal gland; and of stimulating the right splanchnic nerves, 4:49-:51 and 5:23-:25, with right adrenal gland present.] Elliott’s evidence that in the cat the splanchnic innervation of the adrenals is not crossed has already been mentioned. If the gland is removed on one side, therefore, stimulation of the nerves on that side causes no discharge from the opposite gland. As the above experiments clearly show, splanchnic stimulation on the glandless side results in no shortening of the coagulation time; whereas, in the same animals, stimulation of the nerves on the other side (still connected with the adrenal gland) produces a sharp hastening of the clotting process. The splanchnics innervate the intestines and liver even though the adrenal gland is removed. The foregoing experiments indicate that the nerve impulses delivered to these organs do not influence them in any direct manner to accelerate the speed of coagulation. Indeed, in one of the experiments (Dec. 4, see Fig. 31) a high reading about ten minutes after splanchnic stimulation on the glandless side suggests the possibility of an opposite effect. Direct stimulation of the hepatic nerves on one occasion was followed by a change of the clotting time from 4.5, 5, 4.5, 4.5 minutes during twenty-five minutes before stimulation to 4.5, 7, and 6 minutes during twenty minutes after stimulation. Since with the adrenals present stimulation of hepatic nerves induces alteration of glycogen in the liver and quick increase of blood sugar,[110] just as splanchnic stimulation does, the failure of the blood to clot faster after stimulation of the hepatic nerves confirms the evidence already offered that faster clotting when adrenin is increased in the blood is not due to a larger amount of sugar present (see p. 159). The liver and intestines cannot be made to shorten clotting time by stimulation of their nerves, but, as has already been shown (see p. 157), neither can adrenin act by itself to hasten the clotting process. Apparently the effect is produced by coöperation between the adrenals and the liver (and possibly also the intestines). Somewhat similar coöperation is noted in the organization of sugar metabolism; splanchnic stimulation in the absence of the adrenal glands does not increase blood sugar,[111] and in the absence of the liver adrenin is without influence.[112]