The variations of effect noted after splanchnic stimulation can be accounted for by variations in the adrenin content of the glands. Elliott[113] found, as previously stated, that animals newly brought into strange surroundings may have a considerably reduced amount of adrenin in their adrenals. The animals used in our experiments had been for varying lengths of time in an animal house in which barking dogs were also kept, and were therefore subject to influences which would be likely to discharge the glands. The evidence that stimulation of splanchnic nerves, with accompanying increase of adrenal secretion, results in more rapid clotting of blood is especially interesting in relation to the experiments previously described, which showed that in pain and emotional excitement there is an increased secretion of adrenin into the blood. Does the adrenin thus liberated have any effect on the rate of coagulation? The observations here recorded were made in order to obtain an answer to that question. Coagulation Hastened by “Painful” Stimulation In the experiments on the action of stimuli which in the unanesthetized animal would cause pain, it will be recalled that faradic stimulation of a large nerve trunk (the stump of the cut sciatic) and operation under light anesthesia were the methods used to affect the afferent nerves. Elliott[114] found that repeated excitation of the sciatic nerve was especially efficient in exhausting the adrenal glands of their adrenin content, and also that this reflex persisted after removal of the cerebral hemispheres. It was to be expected, therefore, that with well-stored glands, sciatic stimulation, even in the decerebrate animal, would call forth an amount of adrenal secretion which would decidedly hasten clotting. The following case illustrates such a result: Dec. 12.--A cat was anesthetized with ether at 3.45 and the left sciatic nerve was bared. Decerebration was completed at 3.57. The clotting time of the blood began to be tested six minutes later: 4.03--4 minutes .08--3.5 “ .13--3.5 “ .18--4.5 “ .23 to .25 Stimulation of left sciatic. 4.26--2.5 minutes .29--3.5 “ .34--4 “ .40--5 “ .45 to .50 Stimulation of left sciatic. 4.53--2.5 minutes .57--7 “ 5.06--7.5 “ .15 to .17 Stimulation of left sciatic. 5.17--4 minutes .22--4.5 “ .27--5.5 “ .36--5.5 “ .46--7 “