2.08--6 minutes .15--4 “ Anesthesia light. .20--2 “ .24--1 “ Etherization begun again. .27--2.5 “ .30--3.5 “ .35--5.5 “ .50--5.5 “ In the foregoing and in other similar instances, a condition of surgical injury, whether just made or being made, was accompanied by more rapid clotting of blood when the degree of anesthesia was lessened. This condition was one which, if allowed to go further in the same direction, would result in pain. Both direct electrical stimulation and also surgical operation of a nature to give pain in the unanesthetized animal result, therefore, in faster clotting. It is worthy of note that after decerebration clotting apparently occurred no faster because the abdomen had been opened, although in the decerebrate state etherization was suspended. The mechanism for reflex control of the adrenals may not be higher than the corpora quadrigemina, as Elliott has shown, but the discharge from the glands seems to be more certain to occur when the cerebrum is present and is permitted even slightly to operate. Coagulation Hastened in Emotional Excitement The evidence for emotional secretion of the adrenal glands has already been presented. As was noted in my earlier observations on the motions of the alimentary canal (see p. 14), cats differ widely in their emotional reaction to being bound; some, especially young males, become furious; others, especially elderly females, take the experience quite calmly. This difference of attitude was used with positive results, the reader will recall, in the experiments on emotional glycosuria; there seemed a possibility likewise of using it to test the effect of emotions on blood clotting. To plan formal experiments for that purpose was not necessary, because in the ordinary course of the researches here reported, the difference in effects on the blood between the violent rage of vigorous young males and the quiet complacency of old females was early noted. Indeed, the rapid clotting which accompanied excitement not infrequently made necessary an annoying wait till slower clotting would permit the use of experimental methods for shortening the process. The animals used on November 11 and 13 (see pp. 175, 176) are examples of calm acceptance of being placed on the holder; and furthermore, these animals were anesthetized without much disturbance. As the figures indicate, the clotting from the first occurred at about the average rate. In sharp contrast to these figures are those obtained when a vigorous animal is angered: Oct. 30.--A very vigorous cat was placed on the holder at 9.08. It at once became stormy, snarling, hissing, biting, and lashing its big tail. At 9.12 etherizing was begun and that intensified the excitement. By 9.15 the femoral artery was tied. The clotting time of the blood for an hour after the ether was first given was as follows: