She herself had seen a number of instances of the worm in the eyes of natives, and thus knew the nature of the affection when she had it herself. It is said in Calabar that they are very difficult to capture. She has never heard of the parasite piercing the skin or conjunctiva. The ordinary guinea-worm (_Filaria medinesis_) under the skin is unknown in Old Calabar. Miss H⸺ acted as dispenser for about a year during the missionary’s absence, and never saw a case of it, nor heard of it occurring during the whole of her residence there. As a result of inquiry I found that other members of the Old Calabar Mission had been affected with _Filaria loa_. 1. A lady, Mrs. M⸺, who for a time had resided with my patient at Iköröfiön. She was in this country this year, but has returned to Old Calabar. While in Scotland the worm was seen in her eye by my patient Miss H⸺ and her sister, who is at present engaged in the study of medicine. The latter saw the worm pass from the one eye to the other, crossing the bridge of the nose under the skin. 2. Mrs. H⸺, the widow of a medical missionary to Old Calabar. I had the opportunity of seeing this lady, and eliciting the following particulars. She was three years in Old Calabar, from 1860 to 1863, at Old Town Station. Here the water-supply was obtained from a spring which emerged from the ground at a little distance from the river. Before use for drinking the water was filtered through a porous stone basin, but it was not boiled. The water for washing was not boiled or filtered, nor were any precautions taken to prevent it coming in contact with the eyes. During part of the time she was at Old Calabar she suffered from worm in the eye, sometimes one, sometimes the other was affected, but never both at the same time. She occasionally had a feeling as if the worm were making its way under the skin at the root of the nose, in the eyelids, or on the temple. The left eye was the one chiefly affected. She was invalided home on account of intermittent fever. She did not suffer from dysentery. The worms troubled her occasionally after her return home, but they never came to the surface at a convenient time for removal till in 1875, when her husband, Dr. H⸺, succeeded in removing a worm from her left eye. She could not now recall the steps of the operation. About a year later another worm was similarly removed by her husband—she thinks from the same eye, and since then she has not experienced any symptoms of filaria. These worms were preserved in spirits, but she fears were, after some years, thrown away.