As in the case of my patient, Mrs. H⸺ noticed that the worms scarcely troubled her at all during winter. It was only in warm weather they were lively. Both ladies occasionally noticed that the worm lay for a short time coiled up and motionless under the conjunctiva. When the worm appeared on the surface Mrs. H⸺ experienced a “biting, nibbling sensation” at the part where the worm was, and the eye became tender and watery, so that she had to keep it closed, but it never produced any severe inflammation. When not under the conjunctiva or skin she was not aware of its presence. 3. The Rev. J. L⸺ went to Calabar in October, 1868, and returned in July, 1872. He often suffered from intermittent fever, on account of which he was invalided, and by medical advice did not return. His recollection of the time and circumstances of the appearance of the worm is now somewhat faint, but he thinks it appeared during the latter part of his residence in Old Calabar, and certainly troubled him after his return home. As far as he remembers, one eye only, and he thinks the right, was affected, but he cannot say with certainty. It only caused slight irritation, and no severe inflammation. It affected the eyelids, he thinks, more than the eye. He recalls one time in particular when, after preaching at Musselburgh, he felt it wriggling under the skin of the upper lid, and directed the attention of some friends to it, and they saw the movement of the worm. The intervals at which it appeared were irregular, but generally pretty long. He never felt the worm in any other part of the body. As far as he can remember, the visits of the worm to the eye or lids did not generally last long—at most two days. No attempt was made to extract it, nor did any doctor see it. He has seen or felt nothing of the worm for the last eight or nine years, at any rate. He did not notice that the worm was influenced in its visits by the external temperature. In addition to these cases among members of the Old Calabar Mission, I may refer to the experience of Dr. Thompstone, who was for eighteen months stationed at Opobo, on the delta of the Niger, and who is in this country at present. He informs me that while he was at Opobo he saw two cases of _Filaria loa_. In the one negro the parasite was situated in the lower eyelid at the inner canthus close to the lachrymal sac—the swelling in that region giving the appearance of dacryocystitis. He tried to press out what he considered the contents of the distended sac, when he observed the coiled-up worm to wriggle away into the orbit, and the swelling disappeared.