that produced by coffee, and resembles in some degree that of opium. Dr. Mantegazza could, in this excited condition, write with ease and regularity. After he had taken four drachms he was seized with the peculiar feeling of being isolated from the external world, and with an irresistible inclination to gymnastic exercise, so that he, who in his normal condition carefully avoided the latter, jumped with ease upon the writing-table without breaking the lamp or other objects upon it. After this a state of torpidity came on, accompanied by a feeling of intense comfort, consciousness being all the time perfectly clear, and by an instinctive wish not to move a limb during the whole day, not even a finger. During this sensation sleep sets in, attended by odd and rapidly-changing dreams; it may last a whole day without leaving a feeling of debility or indisposition of any kind. The author increased the dose to eighteen drachms in one day; his pulse rose in consequence of it to one hundred and thirty-four, and, in the moment when delirium was most intense, he described his feelings to several of his colleagues, who observed him, in the following written words: ‘_Iddio è ingiusto perche ho fatto l’uomo incapace di poter vivere sempre cocheando_’ (this is the expression for intoxication by Coca). ‘_Io preferiscto una vita di 10 anni con Coca che un di 1,000,000 secoli senza Coca._’ After three hours of sleep Dr. Mantegazza recovered completely from this intoxication, and could immediately follow his daily occupation without the least indisposition—on the contrary, even with unusual facility. He had abstained for forty hours from food of any kind, and the meals then taken were very well digested. From this fact, the author finds it explainable that the Indians employed as carriers of the mail are able to do without food for three to four days, provided they are sufficiently supplied with Coca. ‘From these experiments, made repeatedly on himself and on other individuals, Dr. Mantegazza draws the following conclusions:— ‘1. The leaves of the Coca, chewed or taken in a weak infusion, have a stimulating effect upon the nerves of the stomach, and thereby facilitate digestion very much. 2. In a large dose Coca increases the animal heat and augments the frequency of the pulse, and consequently of respiration. 3. In a medium dose (three to four drachms), it excites the nervous system in such a manner that the movements of the muscles are made with greater ease; then it produces a calming effect. 4. Used in a large dose, it causes delirium, hallucinations, and finally congestion of the brain.