It is likewise to the combination and preparing of these three varieties of Coca leaf in our wine that we can attribute this important fact: during more than thirty years, no matter in how large doses taken, _Vin Mariani_ has never produced _cocainism_, nor any other unpleasant effects.[22] _Vin Mariani_ is a diffusible tonic, the action of which is immediate. This action, instead of being localized on a single organ, the stomach, spreads to the whole system. Taken into the circulation, it awakens in its course the retarded functions of every organ, and this is owing to the presence in our preparation of the volatile principles of the plant. Unlike other tonics, the astringent properties of which lead at length to heat and constipation, _Vin Mariani_ does not produce any disorder of the digestive functions; it stimulates them, exerts a refreshing action on the gastric mucous membrane, and on that account so advantageously replaces the preparations of cinchona, iron, strychnine, etc. "There is," says Dr. Mallez, "a form of anæmia to which the attention of physicians has not yet been called, and which yields marvelously to the employment of _Vin Mariani_; we allude to that state of profound depression of the economy, of extremely marked impoverishment of the blood, which also results from the prolonged abuse of balsamics in the treatment of diseases of the urinary passages. "The number of persons who, attacked with blennorrhagia, use cubebs, copaiba, turpentine, etc., to a deplorable extent is considerable. So true is this that, out of a hundred young dyspeptics, we may affirm without fear of being in error that at least forty of them have become so by the use of balsamics. "In like manner, the number of patients affected with urinary gravel whom the prolonged and excessive use of the agents just mentioned, has rendered dyspeptic and then neuropathic is enormous. Like the former, they owe the profound disorder of their digestive functions to the immoderate use of resins and oleo-resins. "It is of the first importance, therefore, to relieve these persons by making them take, after having given them light laxatives and some preparations intended to strengthen the stomach, not iron, not cinchona, not, as we have said above, local tonics, which would be of little if any use, but diffusible tonics, that is to say, those that act upon the local condition and at the same time upon the general condition, and which, moreover, do not constipate.