"It is here that _Vin Mariani_, proves its great advantage and succeeds where other tonics have failed, in stimulating the functions of the stomach. On the one hand by the small quantity of tannin which it contains, on the other through the active principles of Coca, associated with the wine, which serves as a vehicle, exciting the vitality of each organ separately, not, however, without having previously exerted its vivifying action on the mucous membrane of the stomach itself." (_Gazette des Hopitaux_, Nov. 23, 1877.) The analgesic properties of _Vin Mariani_ have received a happy application in clinical laryngoscopy by Dr. Ch. Fauvel. This eminent specialist has made use of it for the past twenty-six years with unvarying success in all affections of the laryngeal mucous membrane, the air passages, and the vocal organs. In granular angina it takes the place of the topical medication and cauterizations which are so often injurious when they are used indiscriminately and to excess. The employment of _Vin Mariani_ rapidly relieves patients of the feeling of heat and tingling which is one of the most annoying symptoms of this very common disease of the throat. (_Gazette des Hopitaux_, May 12, 1877.) Dr. Beverley Robinson recommends _Vin Mariani_ as a heart tonic. Dr. W. H. Pancoast says that _Vin Mariani_ is a valuable preparation and a tonic of the highest merit. Dr. Jules Bouvyer, of Cauteretz, employs it with success in certain affections of the larynx as an adjuvant to the sulphurous treatment. In 1875, in his _Traitement rationnel de la phthisie pulmonaire_, Dr. de Pietra Santa said, page 394: "Among the most renowned practitioners of Paris, Péan, Barth, G. Sée, and Cabrol have promptly adopted the preparations of Coca. Ch. Fauvel prescribes it in affections of the respiratory passages. It is in these diseases that I, too, have had occasion to advise its daily use in the most convenient, the most agreeable, and the most active form—that of the _Vin Tonique de Mariani_." Thus has been realized Réveil's prediction: "This substance (Coca) is destined to take an important rank in therapeutics." In the _Revue de Thérapeutique médicaux-chirurgicale_, June 11, 1876, page 381. Bibliographie: _Dictionnaire Encyclopédique des sciences médicales_, par A. Dechambre, Dr. H. Cottin thus closes his article: "In France, we are using a great deal of Coca wine, and it is tending to take the place of all other tonic wines; it is borne a longer time by the stomach and is more agreeable to the palate. M. Mariani has contributed much to the popularization of Coca by the perfection of his preparations, _vin_, _thé élixir_ and _pâte_. These are the forms at present most employed."