The second inspiration came to me when on one occasion, amid the laughter of my colleagues, I sought to base the study of psychiatry on experimental methods. When in '66, fresh from the atmosphere of clinical experiment, I had begun to study psychiatry, I realised how inadequate were the methods hitherto held in esteem, and how necessary it was, in studying the insane, to make the patient, not the disease, the object of attention. In homage to these ideas, I applied to the clinical examination of cases of mental alienation the study of the skull, with measurements and weights, by means of the esthesiometer and craniometer. Reassured by the result of these first steps, I sought to apply this method to the study of criminals--that is, to the differentiation of criminals and lunatics, following the example of a few investigators, such as Thomson and Wilson; but as at that time I had neither criminals nor moral imbeciles available for observation (a remarkable circumstance since I was to make the criminal my starting-point), and as I was skeptical as to the existence of those "moral lunatics" so much insisted on by both French and English authors, whose demonstrations, however, showed a lamentable lack of precision, I was anxious to apply the experimental method to the study of the diversity, rather than the analogy, between lunatics, criminals, and normal individuals. Like him, however, whose lantern lights the road for others, while he himself stumbles in the darkness, this method proved useless for determining the differences between criminals and lunatics, but served instead to indicate a new method for the study of penal jurisprudence, a matter to which I had never given serious thought. I began dimly to realise that the _a priori_ studies on crime in the abstract, hitherto pursued by jurists, especially in Italy, with singular acumen, should be superseded by the direct analytical study of the criminal, compared with normal individuals and the insane. I, therefore, began to study criminals in the Italian prisons, and, amongst others, I made the acquaintance of the famous brigand Vilella. This man possessed such extraordinary agility, that he had been known to scale steep mountain heights bearing a sheep on his shoulders. His cynical effrontery was such that he openly boasted of his crimes. On his death one cold grey November morning, I was deputed to make the _post-mortem_, and on laying open the skull I found on the occipital part, exactly on the spot where a spine is found in the normal skull, a distinct depression which I named _median occipital fossa_, because of its situation precisely in the middle of the occiput as in inferior animals, especially rodents. This depression, as in the case of animals, was correlated with the hypertrophy of the _vermis_, known in birds as the middle cerebellum.