appeared, and the old trouble came back in full force. In addition, he became somewhat jaundiced, water made its appearance in the abdomen, and a most distressing nausea harassed him day and night. During all this time he managed to do an unusual amount of literary work, that required both knowledge and tact. On his return to New York, he was in a very weak and debilitated condition. The stomach rebelled at almost every kind of food, the belly was distended with water, the nausea intense, the vomiting frequent, and urine high colored, bloody and containing about sixty per cent. of albumen. While in the West an attempt was made to gradually diminish the amount of morphia, but owing to severe illness, was abandoned. Nor did I think it advisable to try again until the general health was better. Upon iron, in different forms (dialyzed, Bland’s pills, and muriated tincture), strychnia, phosphorus and gentian, he gradually improved, and is now just commencing the treatment by gradual reduction. He consumes daily about ten grains, using it subcutaneously. He contracted the habit some five years ago, through its being administered to him hypodermically, during a severe attack of acute articular rheumatism. Two years ago he was broken of the habit by a physician in this city, who pursued the plan of sudden deprivation, with the result of nearly killing the patient. While traveling in Germany, for the purpose of reporting certain facts for his paper, he was suddenly taken with congestion of the brain, accompanied by intense pain and a state of semi-consciousness. A German physician who was called in, not knowing the man’s previous history, gave him a subcutaneous injection of morphia, with the result of re-establishing the habit. Fluid in the abdomen is not a common complication, and when it does occur, crowds the stomach upward, interferes with the circulation of blood in the viscera in the abdominal cavity and renders the nausea and vomiting still more troublesome. The stools voided by morphia-maniacs are sometimes clay-colored, being devoid of biliary coloring-matter. The absence of bile in the intestinal canal allows of decomposition of the food, with the production of ill-smelling gases which regurgitate through the stomach, or pass by the bowels. Constipation is the rule. Sometimes it alternates with severe diarrhœa. In one patient whom I saw, the fæces collected day by day in the bowels, until impaction resulted and the mass was removed, with the greatest difficulty, by means of large enemata and the handle of a spoon. This lady had been using the drug, crude opium, for only eight months. This constipation from hardened condition of the fæces produces irritation, intestinal catarrh, and often hemorrhoids accompanied by an eczematous eruption about the anus. Heartburn, not from an excess of gastric juice, as is so often supposed, but from an acid fermentation of the food, is not an uncommon symptom.