A lady patient of mine, well advanced in years, would save scraps of tin, old bits of rags, glass stoppers of bottles, and the like, setting great store by them. She laughed heartily at her collection, and threw them away one week after her emancipation. Sometimes there is a mawkish sentimentality exhibited toward the opposite sex; sometimes there is mock modesty or direct abhorrence. In the majority of instances these people are great liars, especially about matters concerning their habituation; often also about trivial things, where falsification is absurd and absolutely without excuse. Occasionally there is a loss of connection between ideas in talking, incoherence and silliness. The speech is, as a rule, slow and somewhat drawling, and often interrupted to wet the lips, which become dry and parched. Severe pain in the head and about the region of the heart is sometimes complained of, also in the “small of the back.” In some cases, more especially those of an intensely nervous organization, the prolonged abuse of opium or morphine produces a condition characterized by cerebral excitement, analogous to that of delirium potatorum. These people are, however, less violent, and the affection usually passes away in a short time, without treatment. THE NERVOUS SYSTEM. On the nervous system the effects of opium and morphine are most manifest. Taken at first to relieve pain and disorders of this system, having their chief action upon it at all times, their continued use reacts with deadly intensity. Twitching of isolated muscles, trembling of the hands and of the tongue, when protruded, and occasionally paralysis of one eyelid, are seen. The pains that supervene have no distinctive character, as do those that come from the abuse of chloral. Itching of the whole or parts of the body is sometimes very troublesome. Herpes zoster (shingles), an eruption following the distribution of the nerve filaments upon the trunk, occasionally occurs, as also does urticaria (nettle rash). The very disorder for which the drug was first taken, is, in some instances, aggravated or perpetuated. This was first noticed by Dr. T. Clifford Allbutt[8], of England, and I have seen the same in some instances. In the condition of delirium sometimes occurring, the pupils, usually contracted, are occasionally irregular and dilated. The whole nervous system is unstrung, or more properly, too highly strung, so that it vibrates to little things that in health would pass unnoticed. They jump at the falling of a book or the shutting of a door. Hysterical women still continue to have their customary attacks, sometimes in an aggravated form. The following interesting case history has been kindly sent me by Dr. Judson B. Andrews:—