“The feverish attacks are accompanied by neuralgic affections of the different nerves, principally in the region of the supra-orbital, intercostal and cardiac nerves. The temperature is increased in all cases, varying from 38.5° C. to 40° C. (101.3° F. to 104° F.). The spleen is generally enlarged. The attack is followed by sediments in the urine. In the severest forms of intermittents the patients get delirious when the fever has reached its maximum, cannot be kept in bed and may become maniacal. Both forms cause great weakness and exhaustion, which last during the intervals.” I have seen but two cases that could at all be classed as such. In one there was _no_ fever, and the chill came every morning at daybreak, for three mornings, missed one morning and occurred again the next. It was followed by profuse sweating, that lasted the whole day. In the other case, that of the lady who had used the drug by the mouth for sixteen years, there was fever and some intercostal neuralgia, occurring every other day, for ten days, but not followed by perspiration. A few doses of quinine broke it up. It was for this that I was first called to attend her, her husband believing her to be suffering from malarial fever. In neither of these cases was there any enlargement of the spleen. I then discovered that she was a morphine habituè, much to her chagrin and her husband’s surprise, he never having suspected it. The two following cases are those given as examples by Levenstein:— CASE I.—INTERMITTENT FEVER IN CONSEQUENCE OF MORBID CRAVING FOR MORPHIA. M. H., law student, 24 years old, sent to the Institution by Dr. Ewald in 1874, was suffering from acute articular rheumatism when the first injection of morphia was administered. After his recovery, although not compelled to do so through pain, he continued the injections several times in the day, increasing the doses, for the sole reason that he felt elated by them. The principal symptoms that resulted therefrom were loss of appetite, progressive emaciation, loss of strength, and increased perspiration, which frequently caused the patient to become wet all over while in a cold room and quite quiet. Before his admission into the Maison de Santé he was troubled with feverish attacks, which came on every two or four days, at different times in the day, in the following manner: first there was a chilly feeling for half an hour, followed by heat and profuse sweating. The latter was accompanied by the general symptoms of every feverish attack, enlargement of the spleen also being present. _Present State._—Patient is a tall, muscular man; the examination of the internal organs shows no abnormal condition, excepting an enlarged spleen. Pupils of middle size, equal, reacting well. On December 10, 1875, the afternoon, patient received the last injection of morphia.