December 12. Patient slept in the night. In the course of the day he only feels a little sleepy. The face is red, the skin moist. Toward the evening there is nausea, pressure in the epigastrium, great restlessness, and stomach-ache. Patient moves about in bed, complains of headache, cannot get to sleep. Three relaxed motions. December 22. Patient has had no sleep during the night, three relaxed motions, vomited once. He complains of giddiness, restlessness and palpitation of the heart. In the morning there is a chill followed by heat and profuse sweating. Vomiting, diarrhœa. Until the afternoon he felt very prostrate and exhausted. Between 3 and 5 P.M. he got up. Soon, however, the symptoms of the morning returned again, and pain in the knees, exhaustion and restlessness compel him to go to bed. December 23. Has slept from 2 to 5 A.M. with interruptions. Profuse perspiration, nausea, intense craving for morphia, frequent paroxysms of sneezing. The sickness stopped in the course of the day. At 8 P.M. 30 grains of chloral were given. December 24. Only three hours’ rest. Feels knocked up. One relaxed motion. Much sneezing; craving for morphia. At 9 P.M. 45 grains of chloral were given, but were immediately brought up again. December 25. Patient has had hardly any rest. One relaxed motion. Has been sneezing frequently. Emission of semen. Great prostration, even in the horizontal posture; red cheeks; craving for morphia continues for the whole of the day. Appetite small. At 10 P.M. 45 grains of chloral. December 26. He has slept well during the night, only woke up two or three times. Pressure in the stomach, headache and palpitation of the heart come on now and then in the course of the day. At 11 P.M. 40 grains of chloral were given. December 27. Restless sleep, much interrupted. Patient went about the room on waking up. During the day he complained of heavy pressure in the head. December 28. Patient has slept for about three hours. Sneezing. The red color of the face of the past days was still present to-day. Although tired he could get no rest. Two relaxed motions. In the morning a warm bath with cold douche was given. December 29. Patient has slept for nearly eight hours. Head not well yet. Severe sneezing. He feels better in himself. Toward the evening, however, an uneasy feeling came on in the legs. Three relaxed motions. January 1, 1876. Except the sleep being restless, patient feels well. January 3. Slept only from 3 A.M.; ran about in a restless manner previously. Three relaxed motions. In the afternoon warm bath with cold douche. January 13. The bodily functions are all in a normal condition. General health good. There have been no further attacks of fever. January 14. Patient left the Institution. He has had no relapse. _Urine._—The specific gravity varied from 1.012 to 1.020. Reduction of oxide of copper was noticed.