Dr. E. Jones, of Cincinnati, has kindly written me and inclosed an article[12] of his, bearing directly upon this subject. In it he says: “Did the needle enter an abdominal vein? Several times. The first time I became somewhat alarmed; the patient at once threw up her arms, complained of suffocation, giddiness, excessive fatigue, a severe tingling sensation following the course of the circulation. The countenance was at first livid, then flushed; the eyes became unusually brilliant; slight muscular twitchings, profuse sweating, with cold extremities, and in a few moments complete relaxation was followed by deep sleep, which lasted only four hours, when she awakened, feeling, as she expressed it, ‘ever so much better.’ “The same accident occurred three times, the symptoms much milder, with the exception of a burning sensation of both eyelids of either eye and both lips, which at one time became painfully intense. The above symptoms were produced by an injection of five grains of sulphate of morphia into an abdominal vein. “Being unable to see her for a day or two, I requested my friend, Dr. Geo. E. Walton, who had watched the case with a good deal of interest, to call and give her an injection of two grains, when she put both hands to her head and gave a cry of excruciating agony. A sharp pain darted through her head, which lasted ten or fifteen minutes; also complained of an intense itching of nose and lips, finally passing off, leaving no deleterious effects. The same accident occurred to myself, only in a less degree. These injections were also made in the abdomen.” The patient was a German woman, aged thirty-seven, and weighing about 135 lbs. The case was presumably one of fecal accumulation in the colon, with severe abdominal pains. Dr. W. A. Neal, of Dayton, Michigan, writes in this connection as follows: “No deaths; the only accidents were where a vein was punctured. This produced dyspnœa, great distress, and was usually followed by a chill and the reaction by fever; but in every instance there has been but one chill, and fever once, lasting three or four hours.” Edward T. Wilson, M.B., Oxon., F.R.C.P., Lond., who has a valuable and interesting article on the subcutaneous injection of morphine, in the St. George’s Hospital Reports, for 1869, writes me as follows: “Never either death or accident. Nothing beyond a temporary feeling of faintness, and on two occasions a temporary outburst of urticaria, which soon passed away.” I hardly think these phenomena were due to injection into a vein; indeed, the writer does not endeavor to account for them on this ground. They partake more of the nature of rapid absorption with some idiosyncrasy. Dr. E. C. Seguin makes mention, in the New York _Medical Record_, of a lady thus affected (urticaria) by any preparation of opium taken by the mouth.