membrane in the neighbourhood of the pylorus was found much inflamed, swelled, and covered with a crust of coagulated lymph. * * * * * The affection of the alimentary canal which we have described above, is plainly to be ascribed to the acrid operation of iodine on its mucous membrane. I have never witnessed it in any considerable degree when this medicine had not been taken internally. But I have seen slight pains of stomach, accompanied with copious bilious evacuations, attend its external use. These never proceed to the degree of violence which marks the internal exhibition. Indeed, it is rare to see them in any considerable degree disturb the comfort of the patient. It is not thus when taken into the stomach. The case of the young lady related above, sufficiently shows its deleterious influence. I have never seen any disease of the bowels which more closely resembled the terrific descriptions given by the physicians of India, of the sufferings from the cholera of that country. Yet no medicine varies more in its effects than this. Some persons take it in large doses for a great length of time with perfect impunity; while others, from that peculiar, undescribed and unintelligible state of constitution, called by physicians an idiosyncrasy, are speedily and violently affected by very small doses. Mr. Magendie, whose accuracy is well known, states that he had swallowed a spoonful of the tincture, containing about a scruple of iodine, without any bad effect ensuing. A child, also, four years old, swallowed by mistake a tea-spoonful of the same preparation with equal impunity. These are extraordinary instances, for I have received the account of the death of a fine boy ten years old, who did not survive many hours after having swallowed the largest of the above doses. And a strong man who took this medicine, under my own care, in doses of half grains three times a-day for one week only, was very soon affected in such a manner, that, had the medicine not been immediately interrupted, the most lamentable consequences might have ensued. When this medicine is given internally, and it is often necessary that it should be thus exhibited, it must be used with extreme caution, under the sanction and observation of those who are able to watch its effects, and who are experienced in its virtues. I have never seen a case in which the mismanagement of iodine proved fatal, and cannot, therefore, say whether its long continued use ulcerates the mucous membrane of the stomach in the human body, after the manner described by Orfila. I have no reason to believe that it does, unless the extreme violence of the symptoms, and the obstinacy of the vomiting, should by some be reckoned proofs of such a state. I certainly, however, am inclined to believe that the last mentioned symptom proceeds from inflammation and occlusion of the pylorus, which Orfila describes as the effect of poisoning by iodine.