purpose, because a heavy one tends to give steadiness to the muscles and to disguise the complaint. [2] I have seen in one case a most obstinate suppression of urine. I merely mention the fact, as I have no reason to believe it to be a common effect of the use of iodine. This effect of iodine is frequently complicated with the choleric complaint I have already described; but it is evident that their proximate cause is different, since they also exist separately. The nervous affection is most common, if I may trust my observations, in the mobile constitutions of women; at least nine out of ten cases, which I have seen, were in women, and by far the greater number in young nubile girls. In the latter cases the disease generally excites some hysterical symptoms. This affection differs from chorea. The patient has no difficulty in keeping the affected limbs steady, if not called upon to exert them, and in general exertion is irksome and painful. Like chorea, however, it is always attended with a constipated condition of bowels. The evacuations, also, are uniformly hard, scybulous, and dark coloured. There is certainly a considerable resemblance between the two diseases, but it would be too much to assert that what has been called their proximate cause, or their nature, is the same. Such an idea, however, has been adopted by more than one physician who has seen these cases along with myself. I mention this, not in order to give weight to the opinion, but in order to give my readers a more distinct notion of the form, which the affection we have been considering sometimes assumes. A statement of this kind is more graphical than many descriptions. Mr. Orfila, whose industry and ingenuity in the study of poisons are well known, has not neglected to examine and note the effects of iodine when given in a large dose. He gave it to different animals in the quantity of a dram and two drams. They were in general seized with violent and frequent vomiting. When the contents of the stomach were not soon thrown off, or were altogether retained, the poison was much more speedily fatal. The animals do not seem to have been affected with any other very remarkable symptom. It is stated that they were much dejected, and manifested suffering, though they did not howl, were not paralyzed or convulsed, and were not affected with any of the more violent symptoms by which poisons commonly show their action on the living body. It is plain that much light is not thus thrown on the effects of iodine when exhibited as a remedy; yet when considered along with the appearances after death, we still find a certain analogy. The stomach was generally found corroded by small ulcers of a linear form, which had eaten through the mucous coat. Those parts, also, which were most exposed to the action of the poison, were thinner and more transparent than the others, and were easily torn asunder. The mucous