The first case of scrophula in which I made use of this medicine, was that of a young lady eighteen years of age, who had been affected by glandular swellings of the neck for nearly eight years. She used the solution of hydriodate of potass for a month; the dose varied from ten to twenty drops three times a day, with occasional intermission of a day when the absorption was going on rapidly. At the end of this time she had got perfectly rid of her swellings, and she now (two years since she took the medicine) remains perfectly well. When she discontinued her drops, so far from having been incommoded by them, her health was certainly much improved. There remained several little fistulous sores, which required the assistance of the knife to heal them. The iodine is not equally efficacious in all cases of this kind. Great numbers, however, yield rapidly under its use; but many of them, also, resist its operation. I have never been able to assign even a plausible reason for this difference of its action in scrophula. In general, I have found such cases yield more readily to the internal than to the external use of iodine. The scrophulous glands of children are not so easily affected by iodine as those of persons who have attained the age of puberty, and they are also more liable to a relapse. A female servant in one of the public hotels of Paris, aged thirty-three, married, who had born several children, shewed me a tumor of her right breast she had had about two years. It was not attended with any pain, but had lately somewhat increased, which gave her alarm. About a year before she had been advised by a surgeon to have it cut out. This advice gave her so much uneasiness, that she presented herself at the clinical consultations of M. Dubois. That eminent surgeon immediately distinguished the tumor to be scrophulous; and during three months’ treatment, all the usual remedies of this disease were exhausted without the least effect. A scruple of the ointment of the hydriodate of potass, placed in the axilla at night, completely removed the tumor in about six weeks. This is the only case of a similar kind in which I have used iodine. I have never yet employed it in scirrhus of the breast.[9] [9] My friend Mr. Maunoir, of Geneva, informed me that a little boy from one of the interior towns of Switzerland, was brought to him on account of a swelling of the knee-joint. He had already been under the care of several eminent surgeons, who had all declared the tumor to be a white swelling, and had recommended the amputation of the limb. Such, also, was the opinion of Mr. Maunoir; but finding the friends and the boy himself extremely averse to the operation, he tried the effect of iodine. In the course of a few weeks the tumor, pain, and stiffness of the joint were dissipated, and the boy was running about as formerly.