She was indeed a miserable monument of the effect of iodine. I heard of this young lady a few weeks ago; she was then much better, had in a great degree recovered her looks, and was able to leave off the use of opium almost entirely. Her stomach, however, still remained very weak, and obliged her to be very careful of her diet. The bronchocele had not returned; but the small hard swelling mentioned above remained still very sensible to the touch, but not evident to the eye. * * * * * These are the outlines of a very severe case. I trust that such a one is not likely to occur soon again. But if practice so daring as I have more than once witnessed in London be repeated, we may very soon see even worse accidents than the above. These statements, however, are important, inasmuch as they demonstrate that iodine is not merely a medicine of specific power against bronchocele, but that it dissipates this disease, by virtue of its very important action on the whole absorbent system. I shall take further notice of this property in a future part of my paper. There is an effect of iodine to which I have alluded in the case just quoted, but which is so extremely common, when the remedy has been pushed to an overdose, that it deserves to be noticed at greater length. The anxiety and depression of spirits are so great and persevering as to warrant my considering them as the peculiar effect of iodine, and not the consequence of the great debility which attends the violent and inordinate action of this medicine on the constitution. It is an affection very different from hypochondriacal melancholy, inasmuch as it dwells principally on the present and has no reference to the future. Patients have generally described it to me as a sense of sinking and faintness, which were peculiarly oppressive, and I have heard them complain of it while suffering the most intense pain, as the part of the complaint which was yet the most difficult to bear. This symptom is an almost constant attendant on the violent action of iodine on the system, and frequently makes its appearance in a lesser degree when the medicine acts in a kind and salutary manner. We have now to notice the effect of iodine on the nervous and muscular systems, and this is by far the most interesting part of our paper. It is that also on which the greatest degree of doubt and uncertainty rests.