I should be very glad if the above lines would induce medical men in England--the haunt of hay fever--to test the observation of Helmholtz. To most patients the application with the pipette may be too difficult or impossible; I have therefore already suggested the use of Weber's very simple but effective nose-douche. Also it will be advisable to apply the solution of quinine _tepid_. It can, further, not be repeated often enough that quinine is frequently adulterated, especially with cinchona, the action of which is much less to be depended upon. Dr. Frickhoefer, of Schwalbach, has communicated to me a second case in which hay fever was cured by local application of quinine. [Footnote: Cf. Virchow's 'Archiv.' (1870), vol. li. p. 176.] Professor Busch, of Bonn, authorises me to say that he succeeded in two cases of 'catarrhus aestivus' by the same method: a third patient was obliged to abstain from the use of quinine, as it produced an unbearable irritation of the sensible nerves of the nose. In the autumn of 1872 Helmholtz told me that his fever was quite cured, and that in the meantime two other patients had, by his advice, tried this method, and with the same success. [Footnote: Prof. Helmholtz, whom I had the pleasure of meeting in Switzerland last year, then told me that he was quite convinced that hay fever was produced by the pollen afloat in early summer in the atmosphere.] ******************** VI. VOYAGE TO ALGERIA TO OBSERVE THE ECLIPSE. 1870. THE opening of the Eclipse Expedition was not propitious. Portsmouth, on Monday, December 5, 1870, was swathed by fog, which was intensified by smoke, and traversed by a drizzle of fine rain. At six P.M. I was on board the "Urgent." On Tuesday morning the weather was too thick to permit of the ship's being swung and her compasses calibrated. The Admiral of the port, a man of very noble presence, came on board. Under his stimulus the energy which the weather had damped appeared to become more active, and soon after his departure we steamed down to Spithead. Here the fog had so far lightened as to enable the officers to swing the ship.