Early in the fifteenth century the male line of the Despencers became extinct, and the Lady Isabel, sister of the last Lord Despencer, succeeded to the ecclesiastical honours of the family. Married in the Abbey at the age of eleven to Richard Beauchamp, Earl of Worcester, she was widowed ten years later and found her solace in building an exquisite chapel, known as the Warwick Chantry, in her husband's memory. Her second husband, cousin to the first, was Richard Beauchamp, Earl of Warwick, whom she commemorated in the still more elaborate Beauchamp Chapel at Warwick; but she herself chose to lie at Tewkesbury. Her daughter married Warwick the King-maker and became the mother of two fair girls of most pathetic story. The elder, Isabel, was wedded to George, Duke of Clarence, brother of Edward III,--"false, fleeting, perjur'd Clarence,"--who is supposed to have been murdered in the Tower through the agency of his brother Richard--drowned, the whisper went, in a butt of Malmsey wine. A fortnight earlier his wife and an infant child had died, probably of poison. A son and daughter survived, who, for the royal blood that flowed in their veins, were regarded with uneasiness by the Tudor kings and ultimately sent to the block. The daughter, Margaret Plantagenet, superintended the education of the Princess Mary, and was once described by Henry VIII himself as "the most saintly woman in England." But she was the mother of Cardinal Pole, who had angered the tyrant and was on the Continent out of his reach; so this reverend and gracious lady, at the age of sixty-eight, had her stately head clumsily hacked off by a prentice executioner on Tower Hill, where her innocent brother had perished forty-two years before. The second daughter of the Countess Isabel had an even more pitiful life than her sister's, for her first husband was Prince Edward, the last Lancastrian, and then, after he had been foully slain, she strangely accepted the hand of one of his murderers, Richard of Gloucester, the worst of the Yorkists, by whom she was soon, it would appear, coolly put out of the world. A favourite saying of the county, probably having reference to the extraordinary number and wealth of its religious houses, runs: "As sure as God is in Gloucestershire," but one can hardly read these tragedies of Tewkesbury without feeling that the Devil has been no infrequent sojourner there.