_Methods of Administration and Indications._ With the methods of administration of the myotics we are all so familiar that time need not be wasted in their reiteration, except to refer to a few practical points. In acute glaucoma, and every one knows that in this disease their action is often prompt and sometimes curative, eserin in a strength of one to four grains to the ounce may be instilled with sufficient frequency to establish myosis, and its action in this respect is enhanced if the congestion of the eye is lowered by measures to which I shall refer later. There is a good deal of clinical evidence to indicate that in this type of glaucoma, as well as in the so-called sub-acute varieties, myotic activity is increased by a mixture of pilocarpin and eserin in the same solution, exactly as a mixture of arecalin and eserin is more potent than either of the drugs in separate solution. Prior to the happy advent of technically correctly placed filtering cicatrices, a large number of surgeons depended almost exclusively on the use of myotics in so-called simple, chronic or non-inflammatory glaucoma. This is not the place to introduce a discussion of the comparative value of iridectomy and myotic treatment in simple glaucoma as based upon statistical records. We must wait now for a sufficient period of time and then compare the value of myotic treatment with that of operations by means of which satisfactory filtration is produced. We are somewhat in the position that general surgeons occupied when aseptic methods first became prevalent. We do not usually compare the statistics of early aseptic days with those of the pre-antiseptic period, and I do not think we ought to compare the statistics of myotic treatment with ordinary iridectomy any longer, but that we should wait until we can make a comparison between the results of prolonged myosis and those of an improved modern technic which establishes a permanent filtration. In the meantime the patients who will not or cannot submit to operation must be reckoned with. Doubtless many patients with chronic glaucoma can be satisfactorily managed with myotic treatment, although personally I have always advocated operation when this could be performed, but it cannot always be performed. This rule should guide us, namely, to begin with a comparatively weak solution of the selected drug, for example, as Posey has advocated a tenth of a grain of salicylate of eserin to the ounce, and the strength gradually increased so that at the end of some months the patient is using a solution 1 grain to the ounce; or if the pilocarpin is preferred, solutions in double these strengths. It is my own belief, and that of many who have studied this subject, that if, without eserin irritation, a myosis can be maintained, and if the treatment can be begun early enough, the chances of preserving vision and the field of vision are good. I believe that the two most important