instillations during the twenty-four hours of the number necessary to maintain this myosis are on retiring and if possible in the very early morning, some time between two and four o'clock. Most patients can be taught to wake themselves at the proper period of time, and are little inconvenienced by this disturbance of their sleep. I believe that eserin irritation is most successfully avoided, not by preparations of the myotics in combination with the antiseptics, for example, tricresol, which has been so much advocated, but by ordering very small quantities of the solution, insisting that it shall be frequently renewed and sterilized at each preparation, and that a half an hour after its instillation, during the day time at least, the eye shall be thoroughly flushed with some mild antiseptic solution, for example, boric acid and sodium chlorid. Whether the action of the eserin on the choroidal circulation, which is maintained by Wahlfours, aids in this favorable action of the myotics remains to be proved. It has been maintained by this author and by others who have followed him. The great trouble with myotic treatment is not its lack of efficiency, but the difficulty of carrying it out successfully on ambulant patients, even in the better walks of life. It is hard successfully to maintain in a patient with chronic glaucoma what I may call an eserin life, just as it is hard to maintain in a person with an enlarged prostate a catheter life and escape infection, resulting, if it occurs, in the one instance in a difficult and stubborn conjunctivitis, and in the other in a cystitis. Still, we are obliged to use myotics, and the way to employ them to the patients' best advantage, I have ventured to repeat in spite of the universal familiarity with the methods. Perhaps we may reach that happy day when, especially with improved tonometric methods, increased skill in measuring the rate of filtration and better instruments for determining the light sense, we can anticipate the advent of glaucoma and get ahead of the ocular and visual deterioration which increased tension produces, by performing preventive operations which shall aid nature's filtration channels in the establishment of an artificial one. But increased tension is not the whole story of glaucoma, and a filtering cicatrix is not the last word in surgical therapeutics, and there is much to learn.