Gout, with a section on ocular disease in the goutyLlewellyn, Llewellyn J. (Llewellyn Jones)
Science
Gout, with a section on ocular disease in the gouty
Llewellyn, Llewellyn J. (Llewellyn Jones)
Eye -- Diseases; Gout
The Antiquity of Gout. Prevalence of Gout in the Anglo-Saxon
Period. Views of the Humoralist. The Aphorisms of Hippocrates.
Introduction of the Word Gout. Early Views as to the Nature of
Tophi. The “Honour of the Gout.” That Gout confers Immunity
from other Disorders. Growing Infrequency and Attenuation of
Gout _pp._ 1-13
CHAPTER II
THE PEDIGREE OF GOUT
Tardy Dissociation of Chronic Gout. Identification of Muscular
Rheumatism. Differentiation of Chronic Gout from Arthritis
Deformans. Cleavage of Arthritis Deformans into Two Types.
Elimination of the Infective Arthritides _pp._ 14-20
CHAPTER III
EARLIER THEORIES OF PATHOGENESIS
Garrod’s Theory. Antagonistic Views. Histogenous Theories.
Antecedent Structural Changes. Hepatic Inadequacy.
Hyperpyræmia. Nervous Theories. Growing Scepticism as to
Garrod’s Pathogeny of Gout _pp._ 21-34
CHAPTER IV
DEFINITION, CLASSIFICATION, ETIOLOGY, AND MORBID ANATOMY
Definition. Classification. Suggested Classification
of Articular Gout. Etiology and Morbid Anatomy. Bodily
Conformation and Individual Temperament. Locality, Race,
Climate. Food, Drink, Occupation. Lead Poisoning. Mental and
Physical Over-exertion. Summary. Morbid Anatomy _pp._ 35-58
CHAPTER V
PATHOLOGY OF GOUT-PROTEIN METABOLISM
Revelations of the Bio-chemist. The Formation of Urea. Fate
of the Amino-acids. Seat of Formation of Urea. Amino-acids
in Relation to Gout. The Glycocoll Theory of Gout. Urea
Excretion in Gout. Creatine and Creatinine. Inborn Errors
of Metabolism _pp._ 59-70
CHAPTER VI
NUCLEIN METABOLISM
The Isolation of Nucleic Acid. Researches on Spermatozoa. The
Discovery of Purins. Uric Acid a Derivative of Nucleic Acid.
The Chemistry of Uric Acid and the Purin Bodies. Chemical
Constitution. Properties of Uric Acid. Uric Acid in the Blood.
Gudzent and Schade’s Theories. Organic Combinations. Complexity
of the Problem _pp._ 71-82
CHAPTER VII
SOURCES OF URIC ACID
Exogenous Purins. Exogenous Uric Acid Excretion. Fate of the
Unexcreted Purins. Endogenous Purins. Source of Endogenous
Purins. Proteins and their Derivatives. Amino-acids and
Dicarboxylic Amino-acids. Endogenous Uric Acid Excretion.
Factors influencing Endogenous Uric Acid Excretion.
Physiological Conditions. Pathological States. Ingestion of
Certain Drugs. Synthetic Formation of Uric Acid _pp._ 83-97
CHAPTER VIII
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