FORMATION AND DESTRUCTION OF URIC ACID Distribution of the Enzymes. Stages in Disruption of Nucleic Acid. Destruction of Uric Acid _pp._ 98-106 CHAPTER IX URIC ACID IN RELATION TO GOUT Uric Acid Excretion in Gout. Uric Acid Variations in Acute Gout. Uric Acid Variations in Chronic Gout. Retarded Exogenous Uric Acid Output. Lowered Endogenous Uric Acid Output. Other Anomalies in Excretion in Gout. Purin Metabolism in other Disorders. Purin Metabolism in Chronic Alcoholism and Plumbism _pp._ 107-116 CHAPTER X THE RENAL THEORY OF GOUT Anomalies in Uric Acid Excretion in Gout. Uricæmia in Nephritis. The Relationship, if any, between the Amounts of Uric Acid and of Urea, and Total Non-protein Nitrogen in Human Blood. Uricæmia not necessarily due to Renal Defect. Uricæmia not Peculiar to Nephritis. Uricæmia does not necessarily Portend Gout. To what may be ascribed the Deficient Eliminating Capacity of the Kidney for Uric Acid. Uratic Deposits in Nephritis. Differentiation of Uratic Deposits in Gout and Nephritis. Clinical Associations of Gout and Granular Kidney _pp._ 117-132 CHAPTER XI URICÆMIA IN GOUT Folin and Denis’s Method. Uric Acid a Normal Constituent of Blood. Effect of Exogenous Purins. Uric Acid Content of Blood in Gout. Hyperuricæmia in Non-gouty Arthritis. Variations in Uric Acid Content of Blood independently of Diet. What Relationship, if any, Exists between the Uric Acid Content of the Blood and Attacks of Gout. Discussion of the Foregoing Data. The Significance of Uricæmia. Sources of Fallacy in Uric Acid Estimation. Disabilities of Modern Tests. Need for further Investigations _pp._ 133-148 CHAPTER XII URATOSIS IN RELATION TO GOUT Constitution of Tophi. Mode of Formation. Localisation of Uratic Deposits. The Causation of Tophi. Solubilities of Uric Acid. Tophi in Relation to Uricæmia. Tissue Affinities for Uric Acid. Retention Capacity of Tissues for Uric Acid. Clinical Evolution of Tophi. The Cause of the Inflammatory Phenomena. Non-toxicity of Uric Acid. Are the Precursors of Uric Acid Toxic? _pp._ 149-170 CHAPTER XIII THE RISE OF THE INFECTIVE THEORY Boerhaave’s Forecast of the Infective Theory. Ringrose Gore on Infective Origin. Leucocytosis in Acute Gouty Polyarthritis. Chalmers Watson’s Researches on Gout in a Fowl. Trautner’s Suggestion of a Specific Infection _pp._ 171-176