Intolerance reigned supreme in America almost immediately after its colonization, and the secret Jews who settled there were not permitted to enjoy peace or prosperity. Juan Sanchez of Saragossa, whose father was burnt at the stake, was the first to obtain permission of the Spanish government to trade with the newly-discovered lands. In 1502 Isabella permitted him to take five caravels loaded with wheat, barley, horses and other wares to Española (Little Spain, the large West Indian Island containing Haiti and Santo Domingo), without paying duty. In 1504 he was again permitted to export merchandise to that country. Other secret Jews went to the new places and settled there, some even obtaining positions in the public service. As early as 1511 we hear already of measures taken by Isabella’s daughter, Queen ♦Juana of Castille, against “the sons and grandsons of the burned” who held public office. The Inquisition was introduced there by a decree of that year, and one of its first victims was Diego Caballera of Barrameda, whose parents, according to two witnesses, had been prosecuted and condemned by the same tribunal in Spain. The Inquisitor-General of Spain, Cardinal Ximenes de Cisneros, on May 7, 1516, appointed Fray Juan Quevedo, Bishop of Cuba, his delegate for the Kingdom of _Terra Firma_, as the mainland of Spanish America was then called, and authorized him to select personally such officials as he needed to hunt down and exterminate the Marranos. Emperor Charles V. (1500–1558), with the permission of his former teacher, Cardinal Hadrian (1459–1523), the Dutch Grand-Inquisitor of Aragon who later became Pope (Hadrian or Adrian VI. 1522–23), issued an edict on May 25, 1520, whereby he ordained Alfonso Manso, Bishop of Porto Rico, and Pedro de Cordova, Vice Provincial of the Dominicans, as Inquisitors for the Indies and the islands of the ocean. At first the secret Jews were not the only victims of the persecutions and not even the most numerous among them. “There were many heathenish natives who were forcibly converted by the mighty clerical arm of the Spanish conqueror, but who nevertheless remained at heart loyal to their hereditary belief and practised their idolatrous customs with as much zeal as the fear of discovery and consequent punishment would allow.” Fiendish atrocities were committed in the name of religion against those Indian Marranos, and the fearful persecutions depopulated the country to such an extent that the tyrants themselves perceived that they must desist.