The word _cassine_ belongs to the language of the now extinct Timucua Indians of Florida. Little is known of the language of those people. It has seemed to me that they borrowed the word from the Creeks, who call Ilex cassine _ussie_, leaf tea. Cassine (c-assi-ne) would seem to be this word with a guttural prefix and a suffix _ne_ of unknown meaning. I can not refer the word _dahoon_ to any Indian language. I believe it to be of French origin, “_houx d’Ahon_.” _Youpon_ is Indian, and seems to belong to the language of the long-extinct Waccoons of North Carolina. The word is Catawba, for in Catawba _yáp_, also pronounced “yop,” means wood, stick, and tree. Prof. Lester F. Ward, botanist of the U. S. National Museum, writes: Linné first used “cassine” as a generic name, and applied it to a South African plant (Gen. Ed. Nova: No. 371, 1753, and his Systema Naturæ, ed. 13th, Lipsiæ, 1791). Thomas Walter used it first as a specific name for Ilex (Flor.-Carolina, Loud., 1778). None of these two refer to the origin of the word. Thomas Walter used dahoon as a specific name; Linné copied from him and spells it “duhoon.” Probably Gerard’s explanation of the etymology of those three words is correct, for at the time Walter and Linné wrote the Indian names of plants had been carried abroad by botanists and travelers in this country. CHEMISTRY OF CASSINE. ANALYSIS OF THE LEAVES OF ILEX CASSINE. I quote the following from a paper by F. P. Venable, PH.D., University of North Carolina: Having on hand a small sample of the leaves procured from New Berue during the winter of 1883, it seemed desirable to make an examination of them, to decide, if possible, the presence of any alkaloid or other principle which would make the decoction useful as a beverage. The usual treatment with magnesium oxide, exhaustion with water, separation by means of chloroform, and subsequent purification was adhered to, resulting in obtaining a small amount of a white substance slightly soluble in water, more so in alcohol, and easily soluble in chloroform, which gave distinctly the tests for caffeine, especially the murexide reaction, and very closely resembled a specimen of pure caffeine from Powers & Weightman. This caffeine formed .32 per cent. of the dried leaves. Later on, in May, a much larger supply of the same leaves was gotten from the neighborhood of Wilmington. A more thorough examination of them was then made, with the following results: Water in air-dried samples 13.19 Extracted by water 26.55 Tannin 7.39 Caffeine .27 Nitrogen (on combustion) .73 Ash 5.75