Jaundice: Its Pathology and Treatment: With the Application of Physiological Chemistry to the Detection and Treatment of Diseases of the Liver and PancreasHarley, George
Science
Jaundice: Its Pathology and Treatment: With the Application of Physiological Chemistry to the Detection and Treatment of Diseases of the Liver and Pancreas
Harley, George
Jaundice
JAUNDICE ARISING FROM HEPATIC CONGESTION.
This is one of the most common causes of the disease; but as there are
two kinds of hepatic congestion--active and passive--it will be
necessary for me to make a further subdivision, and consider each of
these separately.
{25} _Jaundice the Result of Active Congestion._
The mechanism of jaundice resulting from active congestion of the liver
is readily explained on physiological grounds.
The congested condition of any gland is unfavourable to secretion. We
all know, for example, that congestion of the kidney is accompanied by
a suppression of the urinary secretion, and that the secretion is
re-established as the congested condition of the organ diminishes. The
suppression of the renal secretion is no doubt due to the engorged
capillaries pressing upon the secreting structure, and ultimate
ramifications of the urine tubes, and thereby annulling their
functions. A similar explanation is equally applicable to the biliary
secretion; and just as it happens in the case of the kidney, that it is
exceedingly rare for a total suppression of its functions to take
place, so with the liver it seldom happens that the congestion is
sufficiently severe to induce complete arrest of the biliary secretion.
We find, therefore, that although there may be yellowness of the skin
and high-coloured urine in such cases, pipe-clay stools are frequently
absent, sufficient bile to tinge the fæces still finding its way into
the intestines.
Undoubtedly it must have occurred to many of my readers, that jaundice
is frequently absent in {26} cases of acute inflammation of the liver,
even running on to suppuration, and that the foregoing theory of the
pathology of such cases is therefore insufficient. At one time I was
puzzled to explain this apparent anomaly, but on subsequent
investigation the true cause became apparent, and instead of the above
fact detracting from, it tended rather to strengthen the theory. If,
for example, we closely examine cases of acute hepatitis without
jaundice, we find they are those in which only a portion of the liver
is affected. It matters not whether it be one lobe or two, the surface
or the centre of the organ, the disease is invariably circumscribed;
and there is enough hepatic tissue left in a sufficiently normal
condition to prevent the constituents of the bile accumulating in the
blood, and producing jaundice. This may even occur, as I have myself
observed, when the disease has run on to suppuration.
The most typical example of jaundice as the result of active
congestion, is to be found in those cases where it supervenes on an
attack of hepatitis, such as is met with in hot climates, where
indolent habits and high living favour portal congestion. It is
occasionally met with in England, however, and is frequently associated
with gastric derangement.
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