Pathological conditions with which jaundice is associated--Those of the liver itself--Those of the bile-ducts--General affections of other organs of the body exerting an influence on the biliary secretion--Zymotic diseases--The effects of certain poisons . . . . . . . . . . . . . . . . . . . . . . . 3 Frerichs's theory of jaundice--Theory of jaundice hitherto most favoured in England--Dr. Budd as its exponent . . . . . . . . 6 Nature of bile--Biliverdine--Bile acids; glycocholic, and taurocholic acids--Cholesterine--Bile resin--Sugar--Inorganic constituents--Specific gravity, reaction, and colour of normal bile . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Manner in which bile is secreted--Liver both a formative and excretive organ--Animals without gall-bladders--Effects of food on the colour and quantity of the bile . . . . . . . . . 11 Is bile essential to life?--Effect on the system of absence of bile in the digestive process--Death from starvation as a result--Benefit derived from an additional quantity of food--Uses of bile in the animal economy--Necessary to the absorption and assimilation of food--Bile as a digestive agent--Its action on the chyme--Experiments on its influence over the absorption of fatty matter--Its relation to the pancreatic juice--Bile taken internally by Caffres . . . . . . 13 General view of the mechanism of jaundice--Two great divisions--Jaundice from suppression, and jaundice from re-absorption--1st subdivision: jaundice arising from enervation, disordered hepatic circulation, and absence of secreting substance--2nd subdivision: jaundice arising from congenital deficiency of the bile-ducts, and from accidental obstruction of the bile-ducts . . . . . . . . . . . . . . . . 19 General view of the pathology of jaundice from suppression, showing how the coloration of the skin, and urine is produced in such cases . . . . . . . . . . . . . . . . . . . . . . . . 20 Mechanism of jaundice as a result of enervation--Influence of nervous system on secretion--Effect of mental emotion on biliary secretion, as observed in dog with biliary fistula--Action of fright in paralyzing nerve force . . . . . 22 Mechanism of jaundice from hepatic congestion--Active congestion--General view of the effects of congestion on glandular secretion--Reason why the biliary secretion is not usually completely arrested--The absence of pipe-clay stools explained--Example of jaundice from hepatic congestion--Jaundice from zymotic disease, and other cases of blood-poisoning, have a similar mechanism--Example of jaundice following upon ague--Effect on the urine--Analysis of the urine a clue to the nature of the case . . . . . . . . . . . . 24