When human gastric juice is obtained direct from the stomach in man, and lead is submitted to its action, definite quantities of lead pass into solution; and, curiously enough, in the normal gastric juice lead sulphate is as soluble as both white lead and litharge. The following two tables give the results of the estimation of the direct action of human gastric juice upon lead. The particular point is that the juice was obtained by the stomach tube from persons who had been given a simple test meal preceded by a twelve hours’ fast; the juice was therefore in a normal condition. The tests gave the following results in the normal stomach: Lead sulphate 0·080 per cent. White lead 0·048 „ Litharge 0·040 „ In the second digestion, in which the analysis of the contents showed the patient to be suffering from the condition known as “hyperhydrochloridia,” the results were-- Lead sulphate 0·046 per cent. White lead 0·042 „ Litharge 0·340 „ A very large number of experiments have also been performed for the purpose of determining the solubility of raw lead glaze, and white lead, in artificial digestions, the digestions having been made up in such a way that they resembled as far as possible in every particular the ordinary stomach contents. The type of digestion used was as follows: Dry breadcrumbs 140 grammes. Hydrochloric acid 5 c.c. Lactic acid 0·1 c.c. Acetic acid 0·1 c.c. Pepsin 1·2 grammes. Milk 1,200 c.c. Digestions were performed with this mixture, and in every case the digest was divided into two portions; each portion was retained at body temperature, with agitation for a couple of hours, and at the end of that time one portion was submitted to analysis. The second portion was neutralized, sodium carbonate and pancreatic ferment added, and digestion carried on for another two and a half hours at body temperature. At the end of this time the pancreatic digest was examined.