We have described these elements as we first observed them in fresh and carmine-stained preparations, in which they stand out very definitely, as the brown masses do not take up the carmine stain. These brown elements, if one knows their characteristic appearance, may very well serve as diagnostic indications for leprous affections, for, according to our experience, one never fails to find them except in very young nodules. Since the discovery and easy recognition of the lepra bacillus, they have indeed lost their value as diagnostic signs, unless one is examining perfectly fresh preparations. Later investigation has proved that these brown clumps are nothing else but collections of lepra bacilli broken down into granules, and they have received from Neisser the well-chosen name of “globi,” as they usually appear in spherical form. Unna declares, in accordance with his view of the position of the lepra bacilli outside the tumour cells in the lymph spaces, that these “globi” are collections of bacilli in the lymph vessels, and that the vacuoles have arisen from the falling out of bacilli in the middle. In particular, Neisser, Touton, and we, ourselves, have opposed this view, in that we have all seen the bacilli definitely in the cells, and have figured them so. In view of the above description of the discovery of bacilli in fresh preparations and of these brown clumps, there can scarcely be any doubt of the position of the bacilli, and of the cellular nature of the brown clumps. Further, it may be noted that in the testicles the “globi” are chiefly in the lumen of the seminal canals, where no lymph vessels exist, and if Unna says of the “globi”[2] that “no one has certainly determined their cellular character,” he must have said this in ignorance of our earlier publications in Norwegian. The above description and the drawings were published by us in 1869 and 1870, in the _Nordiskt Medicinsk Arkiv_. [2] Unna, zur Histologie der Leprösenhaut; in Leprastudien, Monatshefte für practische Dermatologie, Ergänzhungsheft, 1885.