In connection with the vacuole, we have found in a testicle a “globus” with vacuoles, and in the vacuoles small granules which were recognised as remains of the nuclei (_Plate X, Fig. 2_). We add to this the picture of a “globus,” or rather a developing “globus,” with two nuclei, from a skin nodule (_Plate VIII, Fig. 4_). We have seen earlier, however, that the brown clump may lie in the cell without enclosing the nucleus, and also that the nucleus may lie in the middle of the brown mass. Now, if the vacuoles are transformed nuclei, as we believe, then it would be comprehensible that the vacuoles would be absent in many “globi,” and that in others which have developed from multinuclear cells, several vacuoles would be found. That appears, at least, the simplest explanation of their presence. But there are certain very small “globi” with vacuoles, such as are represented in _Plate VII, Fig. 2, c_, and those small vacuoles can scarcely represent nuclei; small “globi” may however arise, as is evident at _x_ and _x^1_ of the same figure, from clumps of bacilli in the cells. The vacuoles of the larger “globi” of _x_ and _x^1_ may indeed possibly represent nuclei, but not the vacuoles in _Plate VII, Fig. 2, a-k_, nor the vacuole in one of the small “globi” in _x^1_. Possibly the vacuoles are also the result of a specific degeneration, either of the bacilli themselves, or of the cell protoplasm lying in the middle of the group of bacilli, but on this we would rather not express an opinion.