The bacilli appear rapidly to break down into granules, and one finds, especially in the seminal canals, globi, sometimes enormously large, as if they were formed by the running together of several epithelial cells. We have found here globi where a nucleus and a little protoplasm were evident (_Plate X, Fig. 3_), and a globus where there lay in the vacuole small fragments stained with Bismarck brown (_Plate X, Fig. 2_). As it has been proved that a man affected with nodular leprosy may beget children, and as the globi lie in the seminal canals, it is not altogether impossible that these may be thrown off with the spermatic fluid, and that in this way the ovum is infected. But as, according to our view, these globi contain only broken down and degenerated bacilli, it must be regarded as very doubtful whether they are still infective. In examining the contents of the seminal vesicles, we have found in them neither bacilli, nor globi, nor any spermatozoa. It is an old conception that lepers suffer from satyriasis. This is, according to our experience, certainly not the case. The leprous testicle is finally completely destroyed by the scar-like contraction of the connective tissue, and one finds only here and there traces of the seminal canals around the globi which they enclose. When the liver is severely affected with leprosy, there are evident macroscopically, fine white, or yellow, streaks or points, which shine through the capsule and are more evident on the cut surface (_Plate IX, Fig. 2_); they evidently lie in the acini. One also finds round cells with bacilli along the portal vessels and in the capsule of Glisson. Here and there we find also scattered bacilli in the acini, and as is evident from a specimen hardened in Fleming’s solution, the bacilli lie in the endothelium of the blood vessels (_Plate IX, Fig. 1_). In the liver cells we have never seen bacilli, but we have found here also, in the vessels, white blood corpuscles containing bacilli (_Plate VIII, Fig. 6_, and _Plate IX, Fig. 1_). The affection of the spleen may also be recognised macroscopically by the yellow streaks and points in its substance (_Plate IX, Fig. 3_), but the affection must be pretty severe to be recognised macroscopically; the cut surface is then somewhat dry. The affection has its seat in the arterial sheaths and the Malpighian bodies; and in this organ also one can in good preparations definitely recognise the position of the bacilli in the cells (_Plate VIII, Fig. 5_). The glands in the hilum of the liver are, when that organ is affected with leprosy, definitely leprous, and the affection of the glands is often more evident than that of the liver itself. In the hilum of the spleen we have once or twice found leprous lymph glands.