The leprous nodes or nodular Lepromata are of different size and colour; their consistence is at first firm and hard; they are but slightly compressible, and show little elasticity. Their form is usually semi-spherical, but they are often oblong. The smallest nodule that we have seen was not more than 1-2 mm. in diameter, and its appearance was so little characteristic, that we had to confirm the diagnosis by excision and microscopical examination. The larger the nodules, the more characteristic is their appearance. As they are almost always seated in the cutis, the epidermis over them is stretched and shiny; it is occasionally normal in colour, but usually at first reddish, later becoming yellow. _The localisation of the nodules is usually characteristic._ They are generally first evident on the face, on the backs of the hands, and on the dorsal surfaces of the wrists, and next on the extensor surfaces of the limbs. They are more rarely seen on the back and nates; on the flexor surfaces of the extremities, on the breast, abdomen, scrotum, and penis, they are quite exceptional; and we have never seen them on the glans penis, the palms or soles, or on the hairy scalp. Leloir has described a leprous affection of the palms of the hands, of which he himself says that it closely resembled a syphilide in that situation. Since Danielssen, with his enormous experience, never saw a leprous affection of the palm of the hand, we incline to believe that the affection which Leloir observed, not only resembled, but actually was, a syphilide. Here in Norway where the people often go barefoot, wading in streams, marshes and rivers, the backs of the feet and the under part of the calves are frequently the seat of the first leprous eruption, not so often in the form of nodules, as of a dense, regular infiltration. Now since, as we have noted above, the face and back of the hands are the usual seats of predilection for the earliest appearance of the eruption, it appears not improbable that this has its explanation in the climatic influences on these parts, possibly influenced by the structure of the skin, especially the cutaneous vessels. That there are peculiarities in the structure of the tissues, which determine the localisation of the poison, one may conclude; for certain organs are never affected with leprosy, in spite of the fact that the poison has evidently at some time circulated in the blood.